Excess Matters

Tag: hormones

  • Fast Like a Girl by Mindy Pelz: Summary, Key Ideas & Review

    The book in one sentence: Women’s fasting keeps failing not because women are doing it wrong, but because the protocols were designed for men. Mindy Pelz builds the first practical system calibrated to the monthly hormonal cycle that actually governs women’s metabolism.

    What Is Fast Like a Girl About?

    Picture this: you’ve done everything right. You’ve tried 16:8. You’ve tracked macros, cut sugar, done the whole low-carb thing. Your male colleague loses 15 pounds in six weeks on the same protocol. You gain two. Then your period disappears. Then your hair starts falling out. Then you decide fasting just doesn’t “work for you.”

    Mindy Pelz spent years watching this exact scenario play out across her functional medicine practice and YouTube channel. Her explanation is blunt: the fasting research that shaped mainstream advice was conducted almost entirely on men. The 16:8 schedule, the uniform daily eating window, the “just stay consistent” mantra: all of it was calibrated to a body operating on a 24-hour hormonal cycle. Women don’t. Women’s hormones run on a monthly rhythm, and every fasting protocol that ignores that rhythm will eventually backfire.

    Pelz is a chiropractor, not an endocrinologist. Worth noting, and worth keeping in mind as you read. She synthesizes real research (Nobel Prize-winning autophagy science, Valter Longo’s immune-reset fasting studies, peer-reviewed work on insulin and estrogen) and extends it into a practical framework she calls the Fasting Cycle: a month-long system that matches fasting length and eating style to the hormonal phase of the menstrual cycle. The framework is her real contribution, and it’s more useful than most of what the mainstream fasting conversation has produced.

    Why Does Fasting Work Differently for Women?

    The short answer is hormones. The longer answer involves a cascading relationship between four of them: Oxytocin → Cortisol → Insulin → Sex Hormones.

    When cortisol spikes (from stress, overtraining, poor sleep, or fasting at the wrong point in the cycle), it triggers insulin secretion. Elevated insulin then suppresses estrogen and progesterone. A woman can follow a technically correct fasting schedule and still see no improvement if cortisol is chronically high. This is why the woman who “does everything right” and still sees no results isn’t broken. Her protocol is breaking her.

    The top of this hierarchy is oxytocin, which Pelz calls the “love hormone.” It’s produced by hugging, meaningful conversation, laughter, petting animals, yoga, sex. Oxytocin directly calms cortisol. That makes the “soft” stuff (rest, pleasure, connection) physiologically upstream of every hormonal outcome. For the overextended, hard-charging woman who responds to a health plateau by adding more discipline and less food, this is the structural argument that the approach itself is the problem.

    Pelz also takes aim at the Failed Five, the five ways conventional diets actively damage female hormonal health:

    • Calorie restriction raises cortisol, which spikes insulin, which suppresses estrogen and progesterone. The deficit that’s supposed to solve weight is suppressing the hormones that regulate metabolism.
    • Poor food quality (industrial seed oils, refined sugars, endocrine-disrupting chemicals) dysregulates hormonal signaling at the cellular level.
    • Chronic cortisol from overtraining, stress, and aggressive fasting during hormonally sensitive phases keeps the whole sex hormone cascade suppressed.
    • Toxic load from roughly 1,000 endocrine-disrupting chemicals in the modern environment interferes with hormone receptor sites directly.
    • One-size-fits-all protocols ignore the monthly rhythm that governs every metabolic process in a woman’s body.

    “Most diets have blindly disconnected you from your body’s design, leading you straight into the arms of frustration, self-doubt, and distrust with your body.”

    This chapter is the one many women have needed to read for a decade. It relocates failure from the woman to the protocol.

    How Does the Fasting Cycle Actually Work?

    The Fasting Cycle divides the menstrual cycle into three phases, each with distinct fasting and eating recommendations. The logic is anchored in what each sex hormone actually needs to function.

    Phase 1: The Power Phase (Days 1-10 and 16-19)

    Estrogen and other sex hormones are at their lowest during these windows. This is when fasting is most beneficial and best tolerated. All six fasting lengths are appropriate here. Estrogen production prefers a low-insulin environment, which fasting creates. Eating during this phase follows what Pelz calls “ketobiotic” principles: maximum 50 grams net carbs from vegetables, maximum 75 grams protein per day (excess protein triggers gluconeogenesis, blocking ketone production), and 60-plus percent of calories from healthy fats.

    The protein ceiling surprises a lot of women who’ve been told to maximize intake. Pelz is firm: for women in ketosis, the ceiling matters more than the floor.

    Phase 2: The Manifestation Phase (Days 11-15)

    Estrogen and testosterone peak around ovulation. Fasts should stay at 15 hours or under during this window. Here’s why: when estrogen surges, it releases stored toxins from tissues. Autophagy (triggered by 17-plus hour fasts) simultaneously releases toxins from dying cells. Both happening at once produces what Pelz calls a double detox: nausea, brain fog, anxiety, heart palpitations, hair loss. This is the biological explanation for why women feel terrible fasting “correctly” by the conventional 16:8 standard. They’re fasting during ovulation.

    Eating during this phase shifts toward hormone feasting: more liver-supporting foods (cruciferous vegetables, bitter greens, fermented foods) that help clear the estrogen surge rather than let it accumulate.

    Phase 3: The Nurture Phase (Day 20 through the start of the next period)

    No fasting. Progesterone dominates during this phase, and progesterone requires two specific conditions to synthesize: low cortisol and adequate glucose. Fasting elevates cortisol. Strict low-carb eating starves the glucose pathway. Either one during this phase actively depletes progesterone, the hormone responsible for calm, sleep quality, cycle regularity, and emotional stability.

    If your PMS has been getting worse on a keto-plus-fasting protocol, this is the explanation. Up to 150 grams of complex carbohydrates from whole foods (sweet potatoes, lentils, black beans, squash, wild rice, tropical fruits, berries) are not a dietary concession here. They’re the physiological substrate progesterone requires. The strictest dieters often have the worst PMS because they’re removing the very ingredient their body needs for hormonal stability.

    For postmenopausal women, women on hormonal birth control, or anyone without a regular cycle: Pelz provides the 30-Day Fasting Reset, which runs all three phases over 30 days regardless of biological cycle presence. Same logic, applied to a calendar.

    What Are the Six Fasting Lengths and What Does Each One Do?

    One of the book’s genuinely original contributions is the taxonomy of six fasting lengths, each targeting different biological processes at different hour thresholds.

    • 12-16 hours (Intermittent Fasting): Metabolic baseline. Improves blood sugar, blood pressure, gut microbiome diversity, insulin sensitivity. Entry point.
    • 17-72 hours (Autophagy Fasting): Cellular self-cleaning. Dr. Yoshinori Ohsumi’s Nobel Prize-winning research showed that cells, in the absence of food, eat their own damaged organelles and proteins rather than getting weaker. Most relevant for ovarian health (the thecal cells surrounding follicles), brain health (neurons and mitochondria), and immune function.
    • 24+ hours (Gut-Reset Fast): First length to release stem cells into the gut’s mucosal lining. Useful after antibiotics, hormonal birth control use, or for addressing SIBO or leaky gut.
    • 36+ hours (Fat-Burner Fast): Forces the liver to release stored glycogen. Used for women with weight-loss resistance who have plateaued on shorter fasts.
    • 48+ hours (Dopamine-Reset Fast): Repairs and sensitizes dopamine receptors. Effects show up in the weeks following the fast, not during it: reduced compulsive behavior, improved mood, greater contentment.
    • 72 hours (Immune-Reset Fast): Triggers stem cell regeneration of white blood cells. Valter Longo’s research on chemotherapy patients documented that three days of water fasting causes old, depleted white blood cells to die off and a new population to form.

    The practical implication is that fasting length is a clinical decision, not just a willpower variable. Different lengths address different conditions. Choosing how long to fast matters as much as whether to fast at all.

    A caveat worth making explicit: Pelz’s specific hour thresholds (autophagy at exactly 17 hours, immune reset at exactly 72) are more aspirational than evidence-based. The general principle (different fasting lengths trigger different biological processes) holds up. The precise timing markers extend beyond what published research has demonstrated in human subjects. Pelz is synthesizing real science into an accessible framework, but she doesn’t always flag where the clinical evidence ends and practitioner-derived pattern recognition begins.

    Is Fast Like a Girl Worth Reading?

    Read this if you have tried intermittent fasting and experienced adverse effects: hair loss, worsening anxiety, disrupted cycles, no weight loss despite consistent effort. Read it if you’re perimenopausal or postmenopausal and want a structured way to use fasting without amplifying symptoms. Read it if your PMS has been getting worse on a low-carb or fasting protocol and you want to understand why. The cycle-syncing framework alone is worth the read, because it explains patterns that mainstream fasting advice has consistently failed to address.

    Skip it if you have a history of disordered eating or food restriction. The fasting framework here is developed enough that applying it solo, without support, carries real risk for anyone whose relationship with restriction is complicated. Talk to a therapist or registered dietitian first. Also skip it if you need clinical rigor at research-paper depth. Pelz synthesizes well, but she extends beyond the evidence base in places, and her dismissal of calorie restriction as simply one of the “Failed Five” glosses over a substantial body of literature she doesn’t engage with.

    One caveat: The toxic load framework (the claims about environmental chemicals triggering estrogen surges and double-detox symptoms) is more speculative than the fasting science it sits alongside. The core hormonal logic is sound. The more specific mechanistic claims benefit from additional scrutiny. If you’re managing thyroid conditions, type 2 diabetes, or have a complex medication history, involve a physician before applying the condition-specific protocols in Appendix C.

    Books Like Fast Like a Girl

    BookAuthorBest For
    The Circadian CodeSatchin PandaThe research behind time-restricted eating, from one of the scientists who actually ran the studies
    Fast Feast RepeatGin StephensPractical intermittent fasting guide; more accessible, less hormone-specific
    Eat Like a GirlMindy PelzPelz’s follow-up companion focused on the food side of the framework
    The Longevity DietValter LongoThe science behind extended fasting and cellular regeneration; more rigorous, less practical
    The Menopause ResetMindy PelzPelz’s earlier book focused on perimenopause; deeper dive on hormonal transition without the full fasting framework

  • The Great Menopause Myth by Kristin Johnson: Summary, Key Ideas & Review

    Book in one sentence: Johnson and Claps take a blowtorch to the comforting lies women are told about menopause, and to the wellness industry that profits from keeping them in the dark.

    What Is The Great Menopause Myth About?

    Picture the menopause content ecosystem right now: podcasts, Instagram feeds, telemedicine platforms, celebrity supplement lines. Some of it says embrace your symptoms, they’ll pass. Some says lower your cortisol and take these adaptogens. Almost none of it explains why, by age sixty, women match or exceed men in rates of cardiovascular disease, cognitive decline, and osteoporosis.

    That gap is what Kristin Johnson and Maria Claps built this book to close. The two are founders of Wise & Well, a women’s health practice they started after their own frustrating encounters with conventional menopause care. Johnson is a former attorney with board certifications in nutrition and holistic health; Claps holds credentials in functional diagnostic nutrition. Neither is a physician, which is worth noting upfront. But they’ve spent a decade working alongside frontier medical providers, digging into patient outcome data, and sitting on the clinical advisory board of a nonprofit trying to change the standard of care for menopausal women. They write with the confidence of people who have seen what different approaches actually produce.

    The central claim is both simple and uncomfortable: the current menopause conversation is focused on the wrong target. Hot flashes, night sweats, brain fog, the “midlife belly.” All symptoms of a whole-body signaling loss, not cosmetic inconveniences to ride out. Estrogen and progesterone receptors exist in the brain, heart, bone, skin, gut, bladder, immune system, and more. When those hormones decline, every one of those systems gets the message at once. The book argues that treating menopause as a temporary passage, or as a feminist act of acceptance, leaves women unprepared for the chronic disease trajectory that begins quietly in their forties and accelerates through their fifties.

    What Does Menopause Actually Do to Your Weight?

    A lot of women arrive at perimenopause convinced they’re doing everything right (same eating, same exercise) and still watch the scale climb and the belly expand. Johnson and Claps spend real time on this, and the explanation is more mechanistic than most women get from their doctors.

    Estradiol and progesterone are metabolically protective. Both speed up the rate at which you burn calories. Estradiol plays a specific role in keeping blood sugar stable by improving insulin sensitivity, suppressing hunger through leptin and ghrelin signaling, and supporting adiponectin, the hormone that enables fat loss. When estradiol drops, all of that changes: glucose processing becomes impaired, insulin resistance creeps in, hunger signals go haywire, and fat storage shifts from hips and thighs to the abdomen (visceral fat, which carries the highest health risk).

    Then there’s muscle. Estradiol receptors line muscle cells and regulate muscle protein synthesis. Declining estrogen means the body progressively swaps fat for muscle, slowing metabolic rate further. Johnson and Claps describe this as a cascade rather than a single event:

    • Declining estrogen impairs glucose handling
    • Impaired glucose handling leads to insulin resistance
    • Insulin resistance increases fat storage, especially visceral fat
    • Dysfunctional hunger hormones lead to overeating
    • Muscle loss slows the metabolic rate
    • Poor sleep (also hormone-driven) spikes cortisol, which triggers more fat storage and more overeating

    The book takes direct aim at the “less food, more cardio” reflex most women default to when the weight starts shifting. According to Johnson and Claps, this response reliably makes things worse: it creates a catabolic environment that accelerates muscle loss, impairs recovery, and drives women toward fast-energy carbs and caffeine to compensate. Resistance training and adequate protein (more than most women are eating) are the non-negotiable interventions. Not as an aesthetic choice. As metabolic medicine.

    “The scale should never be the sole determinant of a woman’s state of health. We have seen plenty of ‘thin’ women who are prediabetic with high inflammation markers, and we have seen plenty of women 10 to 20 pounds overweight who have beautiful lipids, blood sugar, and inflammation status.”

    The practical takeaway isn’t that menopause makes weight gain inevitable. The book’s argument is the opposite: the cascade is largely modifiable if you understand what’s driving it and address the right levers. Thin is not the goal. Metabolically healthy is the goal. Those two things are not the same.

    Why the “Just White-Knuckle Through It” Advice Falls Apart

    Johnson and Claps give a name to the problem: the menopause gold rush. With an estimated 1.2 billion women worldwide becoming postmenopausal by 2030, the market opportunity is enormous, and investors, wellness brands, and social media influencers have rushed in. The result is a proliferation of interventions that address visible symptoms and aging aesthetics without touching the underlying disease risk.

    The book draws a line between two approaches to hormone therapy that most women don’t know to ask about:

    MHT (menopausal hormone therapy) is symptom-focused. The goal is to suppress hot flashes and vaginal dryness using the lowest dose that relieves discomfort. This is the standard-of-care approach most providers use. The dose is calibrated to feeling better, not to the levels of estrogen that protect bone, brain, and cardiovascular function.

    HRT (hormone replacement therapy), as Johnson and Claps use the term, is restoration-focused. The goal is to approximate premenopausal hormone levels in order to preserve organ function and interrupt the chronic disease trajectory. This requires higher, individually calibrated doses, regular blood testing (not just symptom tracking), and attention to which types and delivery routes are used.

    That gap matters. A dose sufficient to stop a hot flash is often not sufficient to protect your bones, brain, or heart. If your provider’s measure of success is whether you feel better, you may feel better while remaining at elevated risk. Johnson and Claps note that 80 percent of medical residents report discomfort discussing or treating menopause, so the conversation that ends with a low-dose patch and a three-month follow-up is often the most care women can expect from the standard system.

    Their prescription for this gap is metabolic health first. The “hormones need a healthy host” metaphor runs through the middle section of the book: you wouldn’t invite houseguests into a disorganized home. Hormones are the guests; metabolic health is the house. Studies they cite show that adding hormones without addressing insulin resistance, chronic inflammation, and gut dysfunction can increase cancer and cardiovascular risk rather than reduce it. So nutrition, resistance training, sleep, and stress management are the foundation. Not optional lifestyle additions. Clinical prerequisites for hormone therapy to work as intended.

    What the WHI Study Actually Said (And What Got Left Out)

    If you’ve ever been told by a doctor that hormone therapy causes breast cancer, or had a prescription declined because of “the studies,” Chapter Eleven is the one to hand them.

    The Women’s Health Initiative, which published alarming results in 2002, studied women with an average age of 63 (more than a decade past the average age of menopause). It used conjugated equine estrogen (from pregnant horse urine) combined with a synthetic progestin (medroxyprogesterone acetate). When preliminary results showed an apparent breast cancer risk increase in one arm of the trial, the story became: Estrogen Causes Cancer. Millions of women stopped their prescriptions. Most physicians stopped prescribing.

    What didn’t make the headlines:

    • The absolute risk increase was 0.08 percent (from 4 women per thousand per year to 5)
    • The estrogen-only arm of the same study showed a 23 percent lower rate of breast cancer than the placebo group (a finding that received almost no media attention)
    • WHI investigators themselves have since published corrections clarifying that the findings cannot be applied to younger, healthier women in the perimenopause window

    The book introduces what researchers now call the “timing hypothesis.” Estrogen protects healthy cells; it cannot restore function that’s already been lost. Beginning hormone restoration within ten years of menopause (ideally during perimenopause) yields cardiovascular and neuroprotective benefits that starting later cannot provide. The window is real, and most women aren’t being told it exists.

    Johnson and Claps aren’t arguing that every woman should take hormones. They’re arguing that the widespread provider reluctance rooted in a twenty-year misreading of a flawed study isn’t evidence-based, and that women deserve to know that when they’re making decisions about their own care.

    Is The Great Menopause Myth Worth Reading?

    Read this if you’re in your forties or fifties, feel like the information you’ve been handed about menopause is incomplete, and want an accessible book that connects symptoms to underlying biology rather than treating them as separate problems to manage. Especially useful if you’ve been refused or discouraged from hormone therapy and want to understand the WHI story in full, or if you want a framework that integrates metabolic health and hormone restoration rather than treating them as separate tracks.

    Skip it if you want a single-topic deep dive. For cognitive and Alzheimer’s risk specifically, Lisa Mosconi’s The Menopause Brain goes further and has the neuroimaging data behind it. For a more integrative approach that includes non-hormonal options, Suzanne Gilberg-Lenz’s Menopause Bootcamp is more thorough. Johnson and Claps are comprehensive but not always granular. Some chapters cover a lot of ground quickly.

    One caveat: Johnson and Claps are functional nutritionists and health coaches, not physicians or endocrinologists. That doesn’t invalidate their research synthesis (much of which is more current than what you’ll find in popular physician-authored books). But for clinical decisions around hormone therapy, working with a qualified provider remains essential. The authors say so explicitly, and it’s worth taking seriously.

    Books Like The Great Menopause Myth

    BookAuthorBest For
    The Hormone MythRobyn Stein DeLucaDebunking hormonal hysteria with psychological research
    Menopause BootcampSuzanne Gilberg-LenzIntegrative approach, inclusive of non-HRT options
    The Science of MenopauseLeah KayeClinical deep dive, evidence-first format
    The Menopause BrainLisa MosconiCognitive and Alzheimer’s risk, neuroimaging data
    Unlock Your Menopause TypeHeather HirschIndividualized approach by symptom pattern

  • The Natural Menopause Method by Karen Newby: Summary, Key Ideas & Review

    Book in one sentence: A BANT-registered nutritional therapist walks you through a food-first, supplement-supported framework for managing menopause symptoms without relying on HRT.

    What Is The Natural Menopause Method About?

    Most menopause books land in one of two places. Either they read like a clinical briefing (all evidence, no warmth) or they drift into vague “eat clean, reduce stress” territory that sounds helpful and means almost nothing. Karen Newby’s book sits in a more useful middle ground.

    Newby is a BANT-registered nutritional therapist with a degree in Nutritional Medicine. Her angle is practical: she wants you to understand the biochemistry well enough to make confident choices, then give you specific food, herb, and supplement interventions tied to each mechanism. The book is not anti-HRT. A menopause specialist contributes a foreword positioning HRT as one valid tool among several, and Newby frames her approach as complementary rather than competing. That framing matters, because it keeps the book usable for women across a wide range of circumstances.

    What sets this apart from generic wellness content is the specificity. Newby explains why declining oestrogen produces hot flushes (it disrupts insulin sensitivity and triggers adrenaline surges), why sleep unravels (oestrogen supports serotonin, which is the precursor to melatonin; progesterone supports GABA, the brain’s calming neurotransmitter), and why constipation is a hormonal issue rather than just a digestive inconvenience. Once you know the mechanism, the food recommendations stop feeling arbitrary.

    The Four Shifts: How Newby Structures the Approach

    The book’s backbone is a sequenced protocol called the Four Shifts. Each shift addresses a different physiological layer, and the order matters.

    Shift 1: Reset comes first because of something most women don’t know: the adrenal glands are the body’s backup source of both oestrogen (as the weaker form, oestrone) and progesterone when the ovaries start to wind down. Chronic stress means those same adrenal glands are busy prioritizing cortisol instead. As Newby puts it: “Stress (survival) trumps sex hormones.” Addressing cortisol load before anything else is not a soft wellness suggestion. It is a physiological prerequisite.

    Shift 2: Cleanse focuses on the liver and gut as an integrated oestrogen clearance system. The liver converts oestrogen into less active forms; the gut eliminates them. Disruptions anywhere in this pathway (poor diet, constipation, low microbiome diversity) cause processed oestrogen to be reabsorbed rather than excreted, raising total oestrogen load even as the ovaries produce less. Newby calls this the estrobolome effect, and her interventions address both ends simultaneously: brassicas daily for liver support, fermented foods and ground linseed for gut elimination.

    Shift 3: Rest maps specific food and supplement strategies to the three clinical sleep failure modes she sees in her practice (trouble falling asleep, trouble staying asleep, waking exhausted). Tryptophan-rich foods support serotonin and melatonin production. Magnesium supports GABA. Avoiding tyramine-rich foods near bedtime (cheese, cured meats, wine, chocolate) prevents noradrenaline spikes that keep the brain alert.

    Shift 4: Eat optimizes phytoestrogen intake and nutrient density. This is Newby’s “sparkplug” model: macronutrients are the fuel, micronutrients are the sparkplugs. A car will not run without both. The final shift covers the therapeutic phytoestrogen protocol, whole-food swaps, and supplement quality guidelines.

    The shifts are sequential but not rigid. A woman with severe insomnia might start with Shift 3. The framework is a map, not a prescription, and Newby’s repeated framing is “consistency over perfection.”

    Why Does Blood Sugar Keep Coming Up in a Menopause Book?

    It comes up because it is everywhere. Blood sugar instability is the single highest-leverage variable in the perimenopause symptom picture, and Newby returns to it in nearly every section.

    Here is the short version of the mechanism. Oestrogen helps regulate insulin sensitivity. As oestrogen declines, cells become less responsive to insulin. Foods that produced stable energy at thirty-five now create larger glucose swings at forty-five. Those swings trigger cortisol and adrenaline (already overtaxed at perimenopause). In vasomotor terms, a glucose low triggers an adrenaline surge that causes vasodilation, which is how blood sugar directly drives hot flush frequency. In mood terms, the same low amplifies anxiety, irritability, and the impulse to eat something immediately.

    Newby’s practical protocol is not complicated:

    • A 12-14 hour overnight fast (nothing exotic, just not eating at 10pm)
    • Protein and fat at every meal to slow glucose absorption
    • Never skip breakfast (which extends the cortisol spike from overnight fasting)
    • Caffeine only with food (on an empty stomach, caffeine puts the body into fight-or-flight and raises cortisol directly)

    “I liken sugar to pouring petrol onto a fire — the flames burn really bright and kick out a lot of heat, which can give us a sense of energy; but after this short spike the flames become even smaller than they were before. Putting protein and good fats on the fire I liken to coal — although the flames don’t burn as brightly, more heat is produced and they burn for longer.”

    The food swap table in this section is among the more practically useful pages in the book. The 3pm coffee-and-biscuit ritual (which Newby notes works partly through habituated dopamine cues, not hunger) gets replaced with fresh mint tea, miso soup, tamari seeds, or falafel with hummus. These are crowding-out strategies rather than restrictions.

    She also brings the emotional eating angle into this framework. Physical hunger builds gradually, involves stomach grumbling (the hormone ghrelin), and is resolved by eating. Emotional hunger arrives suddenly, is unrelated to the last meal, and is not resolved by eating (which is why the craving continues after the food is gone). The Japanese have a word for it: kuchisabishii, meaning “lonely mouth.” The dopamine reward system drives craving behavior regardless of hunger state, and ultra-processed foods are engineered to spike that system. Knowing this does not eliminate the craving, but it reframes what is happening: it is a neurochemical response to a product designed to produce it, not a character flaw.

    What About the Weight Changes?

    Weight gain during perimenopause, especially around the middle, follows a specific hormonal logic that Newby explains clearly. As oestrogen declines, the pattern of fat storage shifts from hip and thigh to abdominal, which is a testosterone-dominant pattern. The abdominal fat itself then converts testosterone to oestrogen (through an enzyme called aromatase), which can raise oestrogen load even as the ovaries produce less, creating a feedback loop.

    Phytoestrogens are Newby’s sharpest tool for addressing this pattern directly. These are plant compounds structurally similar to oestradiol that bind to oestrogen receptor sites and modulate them bidirectionally: reducing symptoms from oestrogen excess and relieving symptoms from oestrogen deficiency. NICE guidelines confirm that isoflavones may relieve vasomotor symptoms. Research also supports their role in bone density, memory function, and reduced oxidative stress.

    The three main sources:

    • Isoflavones (soya in cooked or fermented forms): tofu, tempeh, miso, natto, edamame; also chickpeas, lentils, peas
    • Lignans: ground linseed or flaxseed (the highest dietary source), sesame seeds, cashews, brassicas, apples, apricots, cherries
    • Coumestans: soybean sprouts, alfalfa, split peas, pinto beans

    Two practical rules stand out. Cook or ferment soya before eating it (raw lectins may affect iodine uptake and are deactivated by heat and fermentation). Fermented foods also supply the lactic acid needed to absorb phytoestrogens in the first place, which is why kefir, sauerkraut, and miso appear throughout the protocol.

    On the supplement side, Newby’s guidance is quality-first: the form of the mineral matters as much as the dose. Magnesium glycinate or malate over oxide. Zinc citrate or picolinate over oxide. Calcium citrate over carbonate. Many supermarket supplements contain fillers, glycerol, sucrose, and talc, so reading the ingredients list matters more than reading the nutrient label.

    Sage (as herb, tea, or tablet) gets specific mention as an evidence-backed hot flush intervention: research supports reductions in both frequency and severity. Red clover isoflavone supplements similarly have research backing for vasomotor symptoms and mood.

    Is The Natural Menopause Method Worth Reading?

    Read this if you are in perimenopause or approaching it, want to understand the mechanisms behind your symptoms, and are willing to make incremental food-based changes over time. Women who have found generic “eat clean” advice unhelpful will get more traction here because Newby explains the biochemistry behind each recommendation. Women who are not on HRT (by choice, contraindication, or circumstance) will find a comprehensive food-first toolkit that few books in this category match. Women who are on HRT will still find value in the lifestyle layer.

    Skip it if you want a meal plan with precise macros, you are in North America and find UK supplement brands frustrating to source (the food interventions translate; the brand names do not), or you prefer narrative-driven health books (parts of this read more like a clinical reference).

    One caveat: the book covers an enormous amount of territory (biochemistry, recipes, pelvic floor rehabilitation, acupuncture, supplement protocols) in 256 pages. Some sections feel compressed as a result. The supplement lists in particular can feel overwhelming without a background in nutritional therapy. Start with the food interventions and treat the supplement section as a reference to return to.

    Books Like The Natural Menopause Method

    BookAuthorBest For
    The Natural Menopause PlanMaryon StewartBroader lifestyle approach with HRT alternatives
    Eat to Thrive During MenopauseJenn Salib HuberAnti-diet framework with intuitive eating integration
    Healthy HormonesMagdalena WszelakiHormone-balancing nutrition with lab-tested protocols
    The Menopause CompanionKathleen DaviesIntegrative approach covering conventional and natural options
    The Happy Hormone GuideShannon LeparskiPlant-based hormone support with cycle-syncing emphasis

  • Eat Like a Girl by Mindy Pelz: Review, Key Ideas & Notable Quotes

    Why This Book Matters

    Most diet advice was designed for men and adjusted for women as an afterthought. The calorie-counting framework, the idea that weight loss is purely a math problem of intake versus output — these were built on metabolic models developed in mostly male research populations, then applied to female bodies that operate on a fundamentally different clock. Women’s bodies are not running on a stable 24-hour metabolic rhythm. They are running on a monthly hormonal cycle that changes what the body needs, how it processes food, and what it stores or burns — every single week.

    Eat Like a Girl is Dr. Mindy Pelz’s case for eating in sync with that cycle. It is the companion volume to her earlier Fast Like a Girl, which established a fasting framework mapped to the menstrual cycle. Where the first book addressed when to eat, this one addresses what to eat — and specifically how food choices should shift based on which hormones are dominant at any given phase. The book’s most important contribution is not any specific food list. It is the reframe: the symptoms women have been told to push through or medicate — the pre-period carbohydrate craving, the post-ovulation bloating, the perimenopausal sleeplessness and weight gain — are not personal failures or inevitable aging. They are hormonal signals pointing toward specific, addressable imbalances.

    Pelz is a chiropractor by training, not an endocrinologist, and that matters when evaluating her scientific claims. But the practical framework she has developed over years of clinical work and an enormous online community of women experimenting with these ideas is genuinely useful, even where the underlying mechanisms are more contested than she acknowledges.

    Core Framework

    The Hormonal Hierarchy

    Pelz organizes hormonal function around a cascade she calls the Hormonal Hierarchy. At the top is oxytocin — the safety, connection, and bonding hormone. Oxytocin suppresses cortisol. Cortisol, when chronically elevated, drives insulin resistance. Insulin resistance disrupts the sex hormones: estrogen, progesterone, and testosterone.

    The practical implication is that any dietary approach that tries to balance sex hormones while ignoring blood sugar and cortisol is treating downstream effects rather than root causes. A woman eating perfectly by macro standards but sleeping five hours a night, working in a high-stress environment, and skipping meals — her cortisol spike from that lifestyle will overwhelm whatever food choices she makes. The hierarchy gives her a framework for understanding why her “clean diet” is not producing the results she expects.

    Blood sugar is the most actionable lever in the hierarchy, and Pelz’s shift away from calorie counting toward glycemic impact is one of the book’s most useful reframes. Every food choice that creates a large glucose spike triggers a compensatory insulin surge. Repetition of those surges leads to insulin resistance. Insulin resistance deranges sex hormone production. Tracking glycemic impact rather than calories changes the entire decision framework — and it produces meaningful metabolic improvements for most women even before cycle syncing is introduced.

    The Fasting Cycle: Four Phases, Two Eating Styles

    The book’s structural core is the Fasting Cycle — a map of the menstrual cycle divided into four phases, each with its own fasting window and eating style.

    Power Phase 1 (Days 1–10): Hormones are low and estrogen is building. The body can tolerate longer fasting windows — 13 to 72 hours — without the cortisol spike suppressing hormonal activity. Eating style: ketobiotic (under 50 grams net carbs from whole plant sources, 75+ grams protein, healthy fats at every meal).

    Manifestation Phase (Days 11–15 / ovulation): Estrogen, testosterone, and a pulse of progesterone all peak simultaneously. This is Pelz’s highest-hormone moment — the time when fasting should be shortest (13–15 hours maximum) to avoid cortisol interference. Eating style: hormone feasting (150+ grams carbs from whole-food sources, emphasis on diverse proteins for full amino acid coverage).

    Power Phase 2 (Days 16–19): Post-ovulation, hormones dip before progesterone rises. The body can return to longer fasting windows. Eating style: ketobiotic, with added emphasis on foods that support estrogen detox — bitter greens, cruciferous vegetables, fermented foods.

    Nurture Phase (Days 20 through the first day of the next period): Progesterone peaks. Progesterone is a calm, restorative hormone, but it requires a low-cortisol environment to do its work. Fasting during this phase raises cortisol and suppresses progesterone. Pelz’s instruction: no fasting, hormone feasting. Carbohydrate cravings during this phase are a hormonal signal, not a willpower failure.

    For women who do not cycle — due to menopause, surgical intervention, hormonal contraception, or cycle loss — Pelz maps the same framework to the moon cycle: new moon as Day 1, full moon as Day 14.

    Key Ideas

    Carb Cravings Are Hormonal Communication

    This is the reframe that stops many women cold the first time they encounter it. The intense desire for carbohydrates in the week before menstruation is not a character flaw. It is progesterone’s way of telling the body it needs more glucose. Progesterone is a hormone that requires carbohydrates to peak appropriately, and the body’s craving is a request — specific, physiologically grounded, and meaningful.

    The relevant question, Pelz argues, is not whether to honor the craving but how. Processed carbohydrates — cookies, crackers, bread — satisfy the craving chemically while delivering excitotoxins (MSG, aspartame, artificial additives) that raise cortisol and directly suppress progesterone. Whole-food carbohydrates — sweet potatoes, bananas, root vegetables, dark chocolate above 70 percent cacao — satisfy the same hormonal need without the cortisol spike. The difference in outcome for a woman’s pre-period experience can be substantial.

    For anyone who has spent years treating their pre-period hunger as a problem to be controlled rather than a signal to be answered intelligently, this reframe is genuinely disorienting in the best possible way.

    The Estrobolome: Why Gut Health Is a Hormonal Issue

    The estrobolome is the specific community of gut bacteria whose job is to break down estrogen and convert it into a format usable by cells. Without a healthy estrobolome, estrogen cannot be metabolized efficiently — and unmetabolized estrogen is stored as fat, particularly in the belly and breast tissue. This connection between gut bacteria and hormonal symptom load is one of the book’s most scientifically grounded sections and one of the most underappreciated ideas in women’s health writing.

    The estrobolome is depleted by a familiar list of modern factors: antibiotics (in medications and food), birth control pills, alcohol, highly processed diets, and environmental pollutants. This means that many of the hormonal symptoms women attribute to “estrogen dominance” or “low estrogen” may actually reflect impaired estrogen metabolism — a problem addressable through the gut rather than through prescription hormones.

    Pelz’s rebuild protocol is the Three Ps: probiotics (raw fermented yogurt, kefir, sauerkraut, kimchi, miso, tempeh), prebiotics (garlic, onions, leeks, asparagus, dandelion greens, flaxseed, chicory root), and polyphenols (dark chocolate, berries, cloves, green tea, olives, flaxseed meal, artichokes). The three categories work synergistically: probiotics introduce new beneficial strains, prebiotics feed and strengthen existing bacteria, and polyphenols specifically regrow the hormone-metabolizing strains of the estrobolome.

    Ketobiotic Eating: Modified Keto That Keeps the Plants

    Pelz’s ketobiotic approach is worth distinguishing from conventional ketogenic diets, because it departs from keto in the one way that matters most for long-term adherence and hormonal health. Standard keto eliminates or severely restricts all carbohydrates, including from vegetables and fruit. Ketobiotic keeps net carbohydrates at or below 50 grams per day but draws all of those carbohydrates from whole plant sources: leafy greens, cruciferous vegetables, berries, kiwi, cantaloupe, avocado.

    The practical difference is substantial. A ketobiotic plate is built around vegetables with protein and healthy fat — not around bacon and cheese. The fiber and phytonutrients in those vegetables directly support the estrobolome (Rule 2) and the liver’s hormone detoxification function (Rule 3). A conventional ketogenic diet, despite producing insulin sensitivity improvements, can deplete the gut microbiome and impair estrogen metabolism if it is not also rich in plant foods.

    Pelz’s protein target of 75 grams minimum per day — scaling up to 1 gram per pound of ideal body weight for muscle building — is consistent with emerging research on protein requirements for women, particularly perimenopausal and post-menopausal women at risk of muscle loss. More muscle means more insulin receptor sites, better glucose utilization, and reduced fat storage. This is one of the areas where the book’s guidance aligns well with mainstream evidence.

    Alcohol and the Menopausal Liver

    Pelz makes a point about alcohol that is clinically important and not often stated directly enough: alcohol temporarily halts the liver’s ability to metabolize hormones. Not impairs — halts. While the liver is processing alcohol as the toxin it is, it is not breaking down estrogen, progesterone, cortisol, or thyroid hormones. Once the alcohol is cleared, it resumes. The problem is the timing.

    For perimenopausal women already experiencing declining progesterone and rising anxiety, the nightly glass of wine to take the edge off is almost certainly making the underlying hormonal situation worse. The anxiolytic effect of the alcohol is real and short-term. The suppression of hormone metabolism during the liver’s detox window, night after night, compounds the very anxiety it is being used to address. Pelz’s suggested maximum for perimenopausal and post-menopausal women is two drinks per week. For many of the women this book targets, that number is substantially lower than their current intake.

    Menopause as Navigation, Not Deficiency

    The book’s most valuable section for its primary audience is the chapter on menopause and the guidance for women who no longer cycle. Rather than framing menopause as a hormone deficiency requiring replacement, Pelz frames it as a navigation challenge: the body is shifting its primary hormone production site from the ovaries to the adrenal glands, and symptoms reflect how well or poorly that transition is supported by lifestyle.

    The symptom-mapping framework is specifically useful: hot flashes, night sweats, vaginal dryness, cognitive changes, and bone loss indicate declining estradiol and call for more ketobiotic days. Insomnia, anxiety, breast tenderness, increased hunger, and difficulty fasting indicate declining progesterone and call for more hormone feasting days and less fasting. For a post-menopausal woman whose symptoms shift week to week, this gives her a decision framework that is responsive to what her body is signaling rather than fixed to a protocol designed for a body that no longer applies.

    Notable Quotes

    “Your hormones are not a negative part of your humanness; they are your superpowers. The fact that you can be happy one moment, then crying the next is part of your authentic feminine nature. Your hormonal landscape is intricate and sophisticated.” — Chapter 7

    One of the book’s most direct challenges to the cultural framing of hormonal variability as pathology. Pelz is making a structural argument: emotional range is hormonal information, not disorder.

    “One reason so many women are experiencing a dysregulation in their metabolic systems is because they’ve been trained to count calories to lose weight. A low-calorie diet can still create mayhem in your metabolic system. Focusing on blood sugar puts not only your metabolic system back into harmony but it can also calm a raging nervous system and regulate even the craziest of hormonal challenges.” — Chapter 1

    The foundational reframe. Caloric deficit is insufficient as a metabolic model for women because it ignores the hormonal cascade triggered by blood sugar spikes.

    “Belly fat is a huge burden for many women, especially menopausal women… Perhaps the worst part about belly fat is that you can’t diet or exercise your way out of it. That’s because this is one of the areas where your body stores all the excess hormones it can’t metabolize and detox out of you, especially cortisol and estrogen.” — Chapter 3

    This repositions belly fat as a hormone storage and metabolism problem rather than a caloric surplus problem — which changes both the intervention and the self-blame calculus for women who have tried everything and not moved it.

    “When you drink, you temporarily halt your liver’s ability to metabolize hormones. Once your liver has cleared the alcohol, it will go back to the business of breaking down hormones. Where I see this challenging women the most is during their perimenopausal years.” — Chapter 3

    A clinically useful point that is rarely stated this directly in popular health writing. The nightly glass of wine is not a neutral coping tool for hormonal anxiety — it is actively compounding the problem.

    “The carbohydrate cravings many women experience during the Nurture Phase are not a failure of willpower. They are a hormonal signal that your body needs more glucose and a wider range of amino acids to support rising progesterone.” — Chapter 8

    The single most useful reframe in the book for the specific experience of pre-period hunger. The craving is not a character problem. It is a hormonal request.

    “If you learn to eat like a girl — in a way that helps you produce, metabolize, and detox your hormones — you will find yourself living in a body you love.” — Chapter 3

    The book’s organizing promise. Worth holding alongside the critical note: for women with access to a cycle, specific food sensitivities, and the capacity to track and experiment, this promise is meaningfully achievable. It is overstated as a universal outcome.

    “The estrobolome is the specific community of gut bacteria whose job is to break down estrogen. Without these key microbes, estrogen can’t get reformatted for cellular use.” — Chapter 3

    The concept that most readers will not have encountered before and that has the most immediate practical implications — particularly for women who have had significant antibiotic exposure, years on oral contraceptives, or a history of highly processed eating.

    Who Should Read This

    This book is most useful for cycling women between roughly 30 and 55 who have already tried conventional dietary approaches and found them inadequate — women whose bodies seem to behave unpredictably in ways that calorie counting does not explain, and who want a framework that accounts for the monthly variation they are actually experiencing.

    It is particularly well-suited for perimenopausal women (roughly ages 40–55) who are dealing with new or worsening symptoms — weight gain that will not move, sleep disruption, anxiety, mood volatility, brain fog — and who want a lifestyle-based framework to explore before or alongside conversations with a healthcare provider about hormone therapy.

    Women on hormonal contraceptives will find the book less immediately applicable, since their natural cycle is suppressed, though Pelz’s general nutritional principles and food quality guidance are valuable regardless of cycle status.

    Women primarily dealing with disordered eating, binge eating, or a history of restriction-driven cycles should approach this book with caution. The framework is not designed for these dynamics, and the emphasis on food quality, fasting, and phase-based restriction could compound existing difficulties without the right support in place. The books in this library better suited to that work include Intuitive Eating, Breaking Free from Emotional Eating, and The DBT Solution for Emotional Eating.

    Related Books

    • Fast Like a Girl — Mindy Pelz: The companion volume on when to eat and fast across the cycle. Essential reading alongside this one; the two books form a complete framework.
    • Intuitive Eating — Evelyn Tribole and Elyse Resch (review on ExcessMatters): The framework most in tension with Pelz’s structured approach. For women whose relationship with food involves restriction history, intuitive eating principles are a necessary counterweight to any protocol-based system.
    • Eat, Drink, and Be Healthy — Walter Willett (review on ExcessMatters): More rigorous evidence base for nutritional guidance. A useful companion for readers who want the research foundation under Pelz’s recommendations.
    • Bright Line Eating — Susan Peirce Thompson (review on ExcessMatters): Another structured eating framework that also dismisses calorie counting in favor of a metabolic reframe. Thompson addresses food addiction neuroscience; Pelz addresses hormonal rhythm.
    • Breaking Free from Emotional Eating — Geneen Roth (review on ExcessMatters): For readers whose primary relationship with the pre-period carbohydrate craving is emotional and shame-based rather than physiological, Roth is the more important starting point.

  • The Science of Menopause by Philippa Kaye: Summary, Key Ideas & Review

    Book in one sentence: A UK GP strips the misinformation out of menopause and replaces it with the actual evidence: hormones, HRT, symptoms, metabolism, and all.

    What Is The Science of Menopause About?

    You ask your doctor about HRT and she says she’s “not really comfortable with it.” You search online and get 457 million results. You find a Facebook group and come away more confused than before. This is the information environment most women are navigating when their bodies start behaving in ways they don’t recognize.

    Dr. Philippa Kaye is a UK GP (general practitioner) and the author of nine books on women’s health. She wrote this one because her consulting room was full of women who didn’t understand what was happening to them, assumed their symptoms were just aging, or were refusing treatments because of clinical trial data from 2002 that was badly misapplied for two decades. The book is structured as a Q&A, so you can open it to “Why am I gaining weight?” or “What is genitourinary syndrome?” and get a direct clinical answer. You can also read it front to back and build a coherent picture of the whole transition.

    At 224 pages, it reads more like a medical briefing than a book. Dense, well-organized, no filler. The tone is what you’d want from a doctor who actually has 30 minutes to talk to you: clear, evidence-grounded, and without an agenda beyond helping you make informed decisions.

    What Does Menopause Actually Do to Your Metabolism?

    This is the section that matters most if weight and eating have been part of your story.

    The average adult gains 1 to 1.5 pounds per year from early adulthood through middle age. That’s not a perimenopause problem specifically. It’s what happens when muscle mass gradually declines with age and nobody replaces it. Muscle burns more calories at rest than fat does, so losing muscle without adding it back creates a slow caloric gap even when nothing else changes. Perimenopause accelerates this process.

    Estrogen also controls where fat gets deposited. As levels fall, fat shifts from the hips and thighs toward the abdomen (visceral fat), and the body simultaneously tries to produce an alternative form of estrogen called estrone from adipose tissue. Visceral fat carries higher metabolic and cardiovascular risk than subcutaneous fat. This is why body composition changes in midlife can feel so different from earlier weight gain (same number on the scale, different distribution, different implications).

    Kaye’s practical recommendation is strength training twice per week as a specific clinical priority, not a general wellness suggestion. The goal isn’t aesthetics. It’s preserving the metabolic engine that’s been quietly losing mass since your thirties. For anyone whose relationship with food and weight has been complicated, this framing is worth sitting with: the changes aren’t a personal failure, and the lever isn’t less food. It’s more muscle.

    “With a lower muscle mass, even if you consume the same amount of food/calories, you will gain weight.” (Philippa Kaye)

    Is HRT Really as Dangerous as Everyone Says?

    The short answer is: the HRT most women are afraid of is not the HRT being prescribed now.

    In the early 2000s, a major US study called the Women’s Health Initiative (WHI) published results suggesting that HRT increased risks of breast cancer and cardiovascular disease. Prescriptions dropped by 50 percent almost overnight. The fear stuck, and it’s still in the room when most women have this conversation with their doctors today.

    Here’s what the coverage got wrong. The average participant in that study was 63 years old. These were not perimenopausal women in their mid-forties. The study also used oral synthetic estrogen and synthetic progestins, formulations that look nothing like what evidence-based practitioners currently prescribe. Kaye walks through the key distinctions:

    • Transdermal estrogen (gel, patch, or spray) bypasses the liver and carries no increased risk of blood clots or stroke. Oral estrogen does carry that risk. Delivery route matters clinically.
    • Micronized progesterone (sometimes called Utrogestan or Gepretix) is body-identical and plant-derived. It carries a much lower breast cancer signal than the synthetic progestins studied in the WHI.
    • Timing matters. HRT started within 10 years of menopause onset may be cardioprotective. Starting much later, in women who already have established cardiovascular disease, carries a different risk profile.

    The WHI findings were real for that population, using those formulations, at those ages. The harm was in applying those conclusions to a completely different group. Kaye doesn’t demonize the researchers. She frames this as a clinical literacy problem, one that has cost women years of unnecessary suffering, bone fractures, and preventable cardiovascular events. Undertreated menopause is its own health crisis, and she makes that case with specifics.

    For women who can’t or don’t want to use HRT, the non-hormonal options get the same rigorous treatment. Fezolinetant (brand name Veoza, FDA-approved 2023) is the first non-hormonal prescription drug specifically targeting the mechanism of hot flashes. SSRIs and SNRIs reduce hot flash frequency by 30 to 60 percent. CBT is clinically validated for hot flashes, insomnia, anxiety, and depression. The book rates each option by evidence quality, which is more useful than a list.

    What About the Symptoms Nobody Talks About?

    Hot flashes get the most airtime, but Kaye explains why they happen in a way most books skip. The hypothalamus keeps body temperature within a narrow range. Estrogen normally moderates a peptide called neurokinin B (NKB). As estrogen falls, NKB overstimulates the thermoregulatory center via NK3 receptors, and the brain reads a temperature emergency that isn’t happening. The body launches its heat-dissipation response: vasodilation, flushing, sweating. Core body temperature doesn’t actually rise. You’re cooling something that isn’t hot. Understanding this mechanism explains why fezolinetant works without hormones: it blocks the NK3 receptor directly.

    Mood symptoms are consistently misidentified. Perimenopausal women are 40 percent more likely to be diagnosed with depression than premenopausal women, and mood changes (anxiety, irritability, low mood, brain fog) often show up before hot flashes do. Women in their mid-forties get put on antidepressants with nobody connecting the symptoms to hormonal fluctuation. Estrogen supports serotonin synthesis and receptor sensitivity; progesterone acts on GABA receptors. As both hormones decline and swing erratically (Kaye’s phrase: “a roller-coaster”), the neurochemical scaffolding for mood stability is progressively removed. HRT can resolve hormonally-driven mood symptoms that antidepressants alone won’t touch.

    Genitourinary syndrome of menopause (GSM) is the symptom with the worst visibility gap. It covers vaginal dryness, painful sex, recurrent UTIs, and urinary urgency, and it affects over half of postmenopausal women. Unlike hot flashes, which often ease over time, GSM is progressive without treatment. Vaginal estrogen is the definitive fix: local application, minimal systemic absorption, safe for most women including breast cancer survivors, reduces UTI frequency by more than 50 percent in studies. It takes three to six months for full effect and should be continued long-term because the condition is chronic. Women don’t report it (stigma, or the assumption that sex is just supposed to hurt now), and clinicians often don’t ask. The silence around GSM costs women years of avoidable suffering that is, in most cases, straightforwardly treatable.

    Is The Science of Menopause Worth Reading?

    Read this if you want one reliable, clinical reference on perimenopause and you’re done wading through wellness influencer content that can’t tell you why hot flashes happen or what micronized progesterone actually is. Kaye treats readers as adults. For anyone who has struggled with weight and wants to understand the metabolic mechanics of this transition (not just “eat less, exercise more”), the muscle mass and fat distribution sections are unusually well-sourced and direct. If you’re on a GLP-1 medication and navigating perimenopause at the same time, the sections on muscle preservation and metabolic rate are directly relevant to how both interventions interact.

    Skip it if you want a diet plan, a step-by-step protocol, or extended personal narrative. This is a reference book. The lifestyle chapter is evidence-grounded but concise: it points to what works and why, without building out full programs. Also worth noting: Kaye is a UK GP, so her treatment recommendations follow NICE guidelines, which sometimes differ from US FDA approvals. The distinctions are flagged in the text, but you’ll need to translate some of it.

    One caveat: The reader rating reflects the fact that some readers found it too dense or too clinical. That’s accurate. It reads like a thorough GP who won’t waste your appointment. Whether that’s a feature or a bug depends entirely on what you showed up for.

    Books Like The Science of Menopause

    BookAuthorBest For
    Menopause BootcampSuzanne Gilberg-LenzA warmer, more lifestyle-forward companion to Kaye’s clinical lens
    The Menopause BrainLisa MosconiGoes deep on the cognitive and neuroprotective angle Kaye covers briefly
    The Great Menopause MythKristin JohnsonFunctional medicine approach, more integrative, less evidence-rigorous
    The Power of HormonesMax NieuwdorpBroader hormonal context, useful for understanding the full endocrine picture
    It’s Your HormonesGeoffrey RedmondUS-focused, clinical, good for understanding HRT formulation options in more depth

  • The Hormone Shift by Tasneem Bhatia: Summary, Key Ideas & Review

    Book in one sentence: An integrative medicine physician maps the full hormone arc from adolescence to post-menopause and offers a sequenced, five-phase protocol for midlife women whose symptoms keep getting dismissed as “just aging.”

    What Is The Hormone Shift About?

    You’ve probably had the experience of eating the way you always ate, moving the way you always moved, and watching your body respond in ways it never did before. Weight collecting around your middle. Sleep unraveling for no clear reason. A fog that settles in around 3pm and won’t lift. You go to your doctor, she runs labs, and then comes the sentence: “Everything looks normal.”

    Tasneem Bhatia, MD (“Dr. Taz”), wrote this book for that moment. She’s a board-certified integrative and holistic medicine physician who founded CentreSpringMD in Atlanta after spending fifteen years watching women cycle through the same pattern: symptoms, dismissal, a prescription for anxiety or sleep, repeat. She’s also been on the receiving end of that dismissal herself. At twenty-eight, her hair was falling out, she’d gained weight, her knees ached, and six separate specialists told her she was fine before she crashed her car after a blood pressure drop caused by a medication none of them had thought to check for interactions. That experience sent her into Chinese medicine, Ayurveda, and Andrew Weil’s Integrative Medicine Fellowship. The book comes from that foundation, not from a wellness brand looking for content.

    The Hormone Shift lands in a gap between two frustrating options: conventional medicine, which tends to minimize or medicate symptoms without investigating the underlying hormonal picture, and the wellness-influencer world, which offers seed cycling and moon rituals without clinical grounding. Bhatia’s approach is both more rigorous than the second and more holistic than the first. She provides specific lab ranges, supplement dosing, and a structured thirty-day protocol. She also takes Chinese medicine and emotional patterns seriously as clinical data. The combination won’t satisfy everyone, but for women in perimenopause who’ve been failed by the conventional approach, it’s worth the friction.

    Why Does Midlife Weight Gain Feel Different?

    A calorie-deficit approach that worked at thirty frequently stops working at forty-five. Bhatia’s explanation for this isn’t complicated, but it’s rarely given plainly: your hormonal environment has shifted, and your body is responding to different signals than it was before.

    Perimenopause (roughly ages 39 to 55 in Bhatia’s framing) involves a declining estrogen-progesterone ratio, rising cortisol sensitivity, insulin resistance that accumulates quietly for years, and thyroid changes that often fall within “normal” lab ranges while producing real symptoms. Each of these independently affects body composition. Together, they create the specific pattern most midlife women recognize: belly fat that wasn’t there before, cravings that are harder to override, and effort that doesn’t produce results.

    The craving map is one of the more useful sections of the book. Bhatia ties specific nutrient deficiencies and hormonal states to specific craving patterns:

    • Low progesterone pulls toward salt
    • Low estrogen pulls toward fat
    • Low iron pulls toward sugar (quick energy)
    • Thyroid disruption produces craving variability that doesn’t follow any predictable pattern

    None of these are willpower failures. They’re the body signaling an imbalance. Restriction-based responses to these cravings often make the underlying problem worse, because severe caloric restriction depletes progesterone, raises cortisol, and can worsen the estrogen dominance that’s driving the weight in the first place.

    Her alternative is what she calls biorhythmic eating: eating when genuinely hungry, anchoring meals around 20 to 30 grams of protein every three to four hours for blood sugar stability, and keeping a twelve-hour overnight fast as a baseline practice. It’s less a diet than an attempt to work with the body’s hormonal timing rather than override it with external rules.

    Bhatia also structures the whole book around a Five Power Types framework, a life-stage map of the female hormonal journey. The stages run from Rock Star (13 to 19), through Hustler (20 to 28), Superstar (29 to 38), Superwoman (39 to 55), and Commander (56+). The practical value is that it stops treating perimenopause as an isolated event. The hormonal patterns in your forties were set up in your twenties and thirties, and the conditions you’re managing now in menopause were shaped by what accumulated before. Knowing your Power Type tells you which hormonal layer to investigate first, rather than throwing every available intervention at the problem simultaneously.

    How Does Your Gut Control Your Hormones?

    Most hormone books treat hormone replacement as the logical first step when symptoms appear. Bhatia’s structural argument is that this is exactly backwards, and the reasoning is biochemical, not philosophical.

    The gut microbiome contains a community of bacteria called the estrabolome. These bacteria produce enzymes that determine how estrogen is metabolized and recycled. When the microbiome is disrupted by antibiotics, processed food, alcohol, stress, or chronic inflammation, the estrabolome becomes dysfunctional. Estrogen then either recirculates in forms that drive excess (estrogen dominance) or gets metabolized poorly, regardless of how much estrogen the body is actually producing.

    “Your gut is ground zero for your health. It processes your food. It gets rid of waste. It produces neurotransmitters. It fights off toxins. And it plays a pivotal role in hormone balance.”

    The practical implication: adding hormones to a compromised gut means the new hormones get mishandled by the same dysfunctional system that’s already mishandling your endogenous hormones. This is why her thirty-day protocol puts gut repair before hormone correction, always.

    The gut-symptom pattern table she includes is worth examining carefully:

    • Chronic constipation maps to estrogen dominance and high insulin
    • Diarrhea and IBS map to low progesterone and sluggish thyroid
    • Bloating maps to thyroid disorders and estrogen/progesterone imbalance
    • Reflux maps to high progesterone and low estrogen

    If you’ve been treating these as digestive problems while also experiencing hormonal symptoms, you may be looking at a single root cause from two different angles. That’s the core observation Bhatia keeps returning to throughout the book: conventional medicine treats these as separate domains, and that separation is where women fall through the cracks.

    What Are “Dirty Hormones” and Why Does It Matter?

    “Dirty hormones” is Bhatia’s term for hormone metabolites, specifically the breakdown products of estrogen that accumulate when the liver can’t clear them efficiently. These metabolites aren’t inert. They act on the body in ways that amplify estrogen dominance, raise DHT (the androgen behind hair loss and acne), and worsen insulin dysregulation. They’re a direct driver of the weight, mood, and body-composition symptoms that midlife women bring to their doctors.

    The liver becomes overburdened by what modern life piles on it: alcohol, processed foods, acetaminophen (Bhatia mentions this specifically), fragranced personal care products, plastics, and pesticide residues. No single exposure is catastrophic in isolation. The aggregate load in a typical modern woman’s life is a different order of magnitude than prior generations carried, and the liver, which is also the primary organ for hormone detoxification, bears the cost.

    Practical reduction starts with the least glamorous interventions. Switch personal care products to fragrance-free and paraben-free. Use glass or stainless steel for food storage. Filter your water. Choose organic for the EWG’s dirty dozen produce list. Reduce alcohol (not necessarily eliminate it, but reduce). Add cruciferous vegetables, dandelion greens, beets, and garlic to support liver function.

    The section on DIM (diindolylmethane), found in cruciferous vegetables and available as a supplement, is one of the most actionable in the book. DIM supports the liver’s Phase 1 and Phase 2 detoxification of estrogen, shifting metabolism away from the more inflammatory estrone metabolites toward safer excretion pathways. For women with estrogen dominance symptoms, such as breast tenderness, heavy periods, weight gain in the hips and thighs, or fibroid growth, this is a high-leverage, no-prescription-required intervention.

    The emotion-hormone section gets its own chapter, and it’s worth taking seriously even if you’re skeptical of TCM frameworks. The core claim is documented physiology: chronic stress elevates cortisol, which competes with progesterone at receptor sites, suppresses thyroid function, raises insulin, and impairs gut healing. Hormonal imbalances in turn produce anxiety, depression, and emotional volatility. The bidirectional loop is not speculative. What Bhatia adds, from her clinical observation, is that major psychological losses (divorce, betrayal, death of a parent) tend to be followed by a hormonal or autoimmune diagnosis approximately eighteen months later. She’s seen this often enough that she anticipates it. Her explanation draws on psychoneuroendocrinology and early mitochondrial science. The evidence is preliminary but coherent.

    Is The Hormone Shift Worth Reading?

    Read this if you’re in your late thirties, forties, or fifties and you’re experiencing weight changes, sleep disruption, mood shifts, or fatigue that your doctor has attributed to stress or aging. Read it if you’ve been told your labs are normal while feeling clearly unwell. Read it if you’ve tried calorie restriction and exercise without results and want a more complete picture of what’s actually driving your body composition.

    Skip it if you’re already working with a knowledgeable integrative medicine physician who’s running full hormone panels and adjusting your protocol accordingly. The book’s value in that case is more as a conceptual framework than a clinical guide.

    One caveat: Bhatia integrates peer-reviewed physiology with TCM frameworks and clinical pattern recognition without always distinguishing between them. The gut-hormone connections and cortisol-progesterone competition are textbook science. The emotion-meridian mapping is more speculative, though it’s clinically consistent with what psychoneuroendocrinology is slowly documenting. Both are useful. They’re not the same level of evidence.

    This is a less dense read than Aviva Romm’s Hormone Intelligence, more clinically grounded than most conventional menopause books, and more integrative in its framework than Anna Cabeca’s The Hormone Fix. For women who want a practical entry point into understanding their midlife hormonal picture, it’s a solid starting place.

    Books Like The Hormone Shift

    BookAuthorBest For
    Hormone IntelligenceAviva Romm, MDMore evidence-focused; stronger on root-cause analysis of modern hormonal dysfunction
    The Hormone FixAnna Cabeca, DONarrower dietary focus; the keto-green approach as a complement to Bhatia’s broader protocol
    Menopause BootcampSuzanne Gilberg-Lenz, MDMore conversational; good for women who find Bhatia’s protocol framework dense
    The New MenopauseMary Claire Haver, MDStrong emphasis on HRT as first-line treatment; less integrative but highly practical
    Eat to Thrive During MenopauseStephanie HuberFood-forward companion for the dietary aspects of hormone balance

  • The Autoimmune Cure by Sara Gottfried: Summary, Key Ideas & Review

    Book in one sentence: Your immune system didn’t go rogue for no reason. For many women, the real trigger is trauma stored in the body, not a broken gene.

    What Is The Autoimmune Cure About?

    You’ve tried to lose weight, cleaned up your diet, done the workouts. The scale barely moves. Your energy is terrible. Your joints ache in the morning. You’ve been told your labs are “normal” and you should feel relieved, but you don’t, because you don’t feel normal at all.

    Sara Gottfried has heard this story thousands of times. In The Autoimmune Cure, she offers a different framing: what if the thing blocking your body’s healing isn’t laziness or willpower, but an immune system that never got the signal to stand down? She argues that subclinical immune dysregulation, often years before any formal diagnosis, is behind a staggering amount of the fatigue, stubborn weight, brain fog, and hormonal chaos that get chalked up to stress or aging.

    Gottfried is not a functional medicine blogger. She trained at Harvard Medical School and MIT, practiced gynecology, and now directs precision medicine at Thomas Jefferson University. She also has her own autoimmune history and an ACE (adverse childhood experience) score of six, which makes her something rarer than a smart clinician: a credible witness. Her central claim, backed by research and her own recovery, is that trauma is the most underappreciated trigger for autoimmune disease (not in a vague metaphorical way, but through measurable disruption to the body’s stress-response, gut barrier, and immune regulation).

    The book is ambitious. It covers everything from childhood adversity scores to elimination diets to the emerging evidence for psychedelic-assisted therapy. Not all of it will be actionable for everyone. But for women who suspect their bodies are fighting something no one has named yet, it maps territory most doctors don’t touch.

    Why Weight Resistance and Autoimmune Inflammation Are the Same Problem

    Most weight-loss frameworks treat the body as a math problem. Eat less, move more, be patient. That model fails spectacularly for a specific group of women, and Gottfried’s work helps explain why.

    Chronic immune activation drives fat storage. When the immune system is in low-grade attack mode, inflammatory cytokines interfere with insulin signaling, disrupt leptin (the hormone that tells your brain you’re full), and promote visceral fat accumulation. The fat itself then produces more inflammatory signals. You end up in a loop that has nothing to do with caloric discipline and everything to do with immune state.

    Gottfried points out that 80 percent of autoimmune disease affects women, and the reasons go deeper than biology. Women carry a disproportionate trauma burden: PTSD rates run at 10 to 12 percent in women versus 4 to 6 percent in men, and women exposed to sexual assault develop PTSD at rates up to 80 percent. Women tend to internalize and somatize trauma (pain, fatigue, gut disruption, hormonal irregularity) rather than the externalized behaviors more visible and more medicalized in men.

    So women’s trauma goes unrecognized as a medical variable even while it is actively driving immune dysregulation and, downstream, weight resistance.

    There’s also the hormonal piece. Estrogen amplifies immune responsiveness. This is protective against infection, but it becomes a liability when the immune system is already dysregulated. Every major hormonal transition (puberty, the postpartum period, perimenopause) represents a window when the immune-endocrine system can tip into autoimmune territory. Women presenting with unexplained weight gain, thyroid symptoms, or metabolic stall at these transitions deserve a closer look at immune markers, not just a new calorie target.

    One of Gottfried’s most useful clinical tools is the ACE (Adverse Childhood Experiences) questionnaire. An ACE score of 2 or higher doubles the risk of rheumatic disease. Higher scores correlate with inflammatory bowel disease, cardiovascular autoimmunity, and metabolic dysfunction. She argues, persuasively, that completing an ACE assessment should be standard in any evaluation of a woman with unexplained weight resistance, chronic fatigue, or inflammatory symptoms. The trauma history is not tangential; it is often the mechanism.

    How Does the Gut Connect to Immune Attack?

    The gut wall, when healthy, is a selective barrier. Nutrients pass through; pathogens and foreign proteins do not. When the tight junctions between intestinal cells degrade (under the influence of chronic cortisol, processed foods, NSAIDs, alcohol, or glyphosate), the barrier becomes porous. Foreign proteins enter circulation, and the immune system mounts a response.

    Gottfried explains the sequence plainly: trauma activates the HPA axis (the body’s stress-response system), cortisol stays elevated longer than it was designed to, and sustained cortisol directly weakens the proteins that hold the gut wall together. So leaky gut is not just a dietary problem. It is, for many women, the physical result of unresolved stress and trauma.

    The mechanism that makes this clinically relevant is called molecular mimicry. The immune system generates antibodies against a foreign antigen, and those antibodies cross-react with structurally similar proteins in the body’s own tissue. The clearest example: gliadin (a component of gluten) shares enough structural similarity with thyroid proteins that a person with gluten sensitivity and genetic thyroid vulnerability may be triggering an immune attack on their own thyroid every time they eat wheat. This is why eliminating gluten can reduce anti-TPO antibodies in Hashimoto’s patients even without a celiac diagnosis. The body is not confused randomly. It’s confused by something it’s being fed.

    Gut repair, in Gottfried’s framework, is non-negotiable. Before targeted immune support, before trauma resolution work, the gut lining has to be addressed. Her approach: remove dietary triggers (gluten, dairy, sugar, alcohol), repair the lining with L-glutamine, zinc carnosine, and collagen, and reinoculate the microbiome with prebiotic fiber and diverse probiotics. It’s not proprietary or exotic. What’s different is the framing: gut repair is not optional supplementation, it’s a prerequisite.

    What Does Gottfried Actually Recommend?

    The protocol is layered deliberately, and Gottfried is explicit that the sequence matters. Jumping to advanced interventions without foundational stability produces poor results.

    Layer 1: Foundation

    Remove gluten, dairy, sugar, and alcohol (and in severe cases, nightshades and legumes). Optimize sleep, targeting seven to eight and a half hours. Anchor circadian rhythms to manage cortisol. Complete a full trauma history via ACE scoring and timeline mapping. This layer is not glamorous, but Gottfried is clear: nothing works well without it.

    Layer 2: Immune Regulation

    Once the dietary foundation is in place, add natural immunomodulators: vitamin D3, omega-3 fatty acids, curcumin, Nigella sativa (black cumin), polyphenols. Layer in gut permeability repair. Monitor inflammatory markers and autoantibody titers in blood work. Low-dose naltrexone (LDN) gets attention here; it has a small but growing evidence base for immune normalization in autoimmune conditions.

    Layer 3: Trauma Resolution

    This is where the book earns its subtitle. Standard talk therapy, Gottfried argues, often cannot reach the level where autoimmune-driving trauma is stored: the subcortical, somatic, pre-verbal layers of the nervous system. Trauma encoded before language existed cannot always be talked out. She advocates for embodied, somatic therapies that work at the level of body sensation and autonomic response: Hakomi mindfulness-based somatic therapy, EMDR, brainspotting, Internal Family Systems, Neuro-Emotional Technique. The goal is not insight. It is physiological repatterning.

    Layer 4: Advanced Therapies

    For people who have completed the first three layers without sufficient resolution, Gottfried presents the emerging evidence for psychedelic-assisted therapy: MDMA for PTSD, psilocybin for treatment-resistant depression (with documented anti-inflammatory effects), and ketamine, which is already legal and widely available through clinics. She is careful here: foundational layer completion is required before Layer 4, and she insists on clinical containers, contraindication screening, and integration support. This chapter will be out of reach for most readers practically, but it is not irresponsible. The research she cites is real.

    Is The Autoimmune Cure Worth Reading?

    Read this if you are a woman who has cycled through conventional care for fatigue, weight resistance, joint pain, thyroid issues, or gut dysfunction without resolution, especially if you have a trauma history that has never been part of the medical conversation. Gottfried’s framework will feel like someone finally asking the right questions.

    Also worth reading if you test positive for autoantibodies but haven’t received a formal diagnosis, if your symptoms span multiple systems without adding up to a clean diagnosis, or if you’re in a hormonal transition (postpartum, perimenopause) and things have shifted in ways no one can explain.

    Skip it if you need randomized controlled trial evidence for the full protocol as a system before acting on it. The individual research Gottfried cites is real, but the protocol has not been tested as a whole in randomized fashion. She is building on mechanistic plausibility and clinical observation, which is honest and probably sufficient for most readers. Not everyone will find that enough.

    One caveat: the psychedelics chapter creates some tonal unevenness. A book that also covers sleep hygiene and basic elimination diets lands in a different register when it pivots to MDMA. Gottfried handles it carefully, but readers who find that section inaccessible should know the rest of the protocol stands entirely on its own.

    “The problem is that conventional medicine treats symptoms, whereas the type of medicine that I practice addresses and aims to resolve root causes.” (Sara Gottfried, MD)

    The book is repetitive in places, and the case studies accumulate like evidence rather than illustration. But the core framework (autoimmunity requires genetic vulnerability, a leaky gut, and a trigger, and for most women the trigger is trauma) is clinically coherent and practically underserved in mainstream health writing. For anyone who has been told their immune disease is “just how they are now,” this is a map with more territory on it.

    Books Like The Autoimmune Cure

    BookAuthorBest For
    Brain Body DietSara Gottfried, MDGottfried’s earlier work on brain-hormone connection; good companion volume
    Women Food and HormonesSara Gottfried, MDMore accessible entry point to Gottfried’s dietary approach
    Hormone IntelligenceAviva Romm, MDOverlaps substantially on hormonal drivers of chronic illness in women
    The Menopause BrainLisa Mosconi, PhDBrain-hormone-inflammation connection for women in hormonal transition
    Eat to Thrive During MenopauseJill HuberPractical nutrition companion for the dietary protocol layer

  • Fast Like a Girl by Mindy Pelz: Review, Key Ideas & Notable Quotes

    Why This Book Matters

    If you’ve ever tried intermittent fasting and made things worse — weight wouldn’t move, periods got irregular, anxiety spiked, hair came out in clumps — you are not broken, and you were not doing it wrong in some personal failure kind of way. You were doing it wrong in the way that everyone was doing it wrong, because the fasting protocols that became popular were designed around research conducted primarily on men.

    Mindy Pelz spent years watching this play out in her practice and on her YouTube channel, where hundreds of thousands of women were testing fasting advice designed for male hormonal patterns and then blaming themselves when it backfired. Her response was Fast Like a Girl — a women-specific fasting framework built around the core biological fact that women’s hormones don’t operate on a 24-hour cycle. They operate on a monthly one.

    This book is not a diet book, and Pelz is explicit about that distinction from the first chapter. Fasting, as she frames it, is a biological tool — a way of triggering specific healing processes inside the body by controlling the timing of eating rather than the content of it. What she adds that almost nobody in the mainstream fasting conversation had articulated clearly before: the timing question is not the same for all women at all times of the month. When you eat matters, but when in your cycle you eat matters just as much.

    For women who have struggled with food, body, and metabolism — and who have quietly wondered why the advice that works for everyone else consistently fails them — this book provides a structural explanation that has nothing to do with willpower.

    The Core Framework: Fasting Synced to Your Hormonal Cycle

    The book’s central concept is what Pelz calls the Fasting Cycle — a system for matching fasting length and eating style to the hormonal phase of the menstrual cycle.

    She divides the cycle into three phases:

    The Power Phase (Days 1–10 and 16–19): Estrogen and other sex hormones are at their lowest points during these windows. This is when fasting is most beneficial and best tolerated. The body uses fasting to clean up damaged cells (autophagy), shift into fat-burning mode (ketosis), and support the natural rise of estrogen that prefers a low-insulin environment. Pelz recommends the full range of fasting lengths during this phase — anywhere from 13 to 72 hours depending on the specific goal.

    The Manifestation Phase (Days 11–15): Estrogen and testosterone peak around ovulation. Fasting should be kept at 15 hours or under. Longer fasts during this window create a dangerous overlap: estrogen surges release stored toxins from tissues, and autophagy (triggered by 17+ hour fasts) releases additional toxins from dying cells. Both happening simultaneously produces what Pelz calls a double detox — nausea, brain fog, anxiety, hair loss, heart palpitations. This is why some women feel terrible when they fast “correctly” by the conventional 16:8 standard. They are fasting during ovulation.

    The Nurture Phase (Day 20 through the start of the next period): No fasting. Progesterone dominates during this phase, and progesterone requires two things to synthesize properly: low cortisol and adequate glucose. Fasting elevates cortisol. Low-carb eating keeps glucose too low. Doing either during this phase actively depletes progesterone — the hormone responsible for calm, sleep, cycle regularity, and emotional stability. Women who have been fasting and eating low-carb in the week before their period and wondering why their PMS is getting worse now have an answer.

    For women without a cycle — postmenopausal, on hormonal birth control, or with irregular periods — Pelz provides the 30-Day Fasting Reset, which runs all three phases over 30 days regardless of cycle presence. It’s the same hormonal logic applied to a calendar, not a biological cycle.

    Key Ideas

    The Failed Five: What Diets Actually Did to Your Body

    Before Pelz introduces fasting, she explains why conventional diets made things harder. She calls them the “Failed Five”:

    1. Calorie restriction — every time you eat less and exercise more, you raise cortisol, which spikes insulin, which suppresses estrogen and progesterone. The calorie deficit that’s supposed to fix your weight is suppressing the hormones that regulate your metabolism.
    2. Poor food quality — industrial seed oils (canola, soybean, vegetable), refined sugars, and environmental chemicals (obesogens, endocrine disruptors) dysregulate hormonal signaling at the cellular level.
    3. Chronic cortisol — overtraining, high-stress lifestyles, and aggressive fasting during progesterone-dominant phases keep cortisol chronically elevated, which sits directly upstream of every sex hormone problem women experience.
    4. Toxic load — roughly 1,000 endocrine-disrupting chemicals in the modern environment interfere with the hormone receptors on cells; phthalates (plastics, commercial fragrances) are particularly destructive to testosterone and progesterone production.
    5. One-size-fits-all — the male-derived, calendar-agnostic approach that has dominated diet culture ignores the monthly hormonal rhythm that governs every metabolic process in a woman’s body.

    This framing is empathetic and useful because it relocates the failure from the woman to the protocol. If you’ve tried and struggled, this chapter may be the one you’ve needed to read for a decade.

    The Six Fasting Lengths: Not All Fasts Are the Same

    One of the book’s most genuinely useful contributions is the taxonom of six fasting lengths, each triggering different biological effects:

    • 12–16 hours (Intermittent Fasting): Improves blood sugar, blood pressure, gut microbiome diversity, and insulin sensitivity. Entry-level — the metabolic baseline.
    • 17–72 hours (Autophagy Fasting): Triggers cellular self-cleaning. Dr. Yoshinori Ohsumi won the 2016 Nobel Prize in Physiology or Medicine for discovering that in the absence of food, cells eat their own damaged parts — organelles, proteins, oxidized particles — rather than getting weaker. Autophagy repairs the cells surrounding the ovaries (relevant for PCOS and fertility), neurons in the brain (memory, mood, neurodegeneration), and immune cells.
    • 24+ hours (Gut-Reset Fast): The first length to release stem cells into the gut’s mucosal lining. Particularly useful after antibiotics, hormonal birth control use, or for gut-related conditions.
    • 36+ hours (Fat-Burner Fast): Forces the liver to release stored glycogen. Used specifically for women with weight-loss resistance who have plateaued on shorter fasts.
    • 48+ hours (Dopamine-Reset Fast): Repairs and sensitizes dopamine receptors. Effects emerge in the weeks following the fast — reduced compulsive behavior, improved mood, greater sense of contentment.
    • 72 hours (Immune-Reset Fast): Triggers stem cell regeneration of white blood cells. Dr. Valter Longo’s research on chemotherapy patients showed that a three-day water fast causes old, depleted white blood cells to die off and a new population to form. It is a literal immune system reboot.

    For women who have been treating “intermittent fasting” as a binary practice — either doing it or not — this spectrum changes the picture entirely. Different lengths address different conditions. The choice of how long to fast is a clinical decision, not just a willpower one.

    The Hormonal Hierarchy: Why Stress Undoes Everything

    Pelz maps a cascading hormonal relationship that explains why the most health-conscious, high-achieving women are often the ones whose hormones are most disrupted:

    Oxytocin → Cortisol → Insulin → Sex Hormones

    Cortisol, spiked by stress, overtraining, poor sleep, and — critically — fasting at the wrong phase, triggers insulin secretion. Elevated insulin then suppresses estrogen and progesterone. A woman can be following a technically correct fasting schedule and still see no hormonal improvement if cortisol is chronically elevated.

    The top of the hierarchy is oxytocin — the bonding hormone produced by hugging, laughing, meaningful conversation, petting animals, meditation, yoga, sex, and genuine connection. Oxytocin directly calms cortisol. This makes the “soft” stuff — rest, pleasure, social connection — physiologically upstream of every hormonal outcome. For the overextended woman who responds to her health problems by adding more discipline and restriction, this is the structural argument that the approach itself is the problem.

    What to Eat: Ketobiotic vs. Hormone Feasting

    Pelz builds two distinct eating modes around the fasting cycle.

    Ketobiotic eating (Power Phase): Modified keto designed for women. Maximum 50 grams net carbs daily (from vegetables, not grains), maximum 75 grams protein (to prevent the gluconeogenesis pathway from spiking blood sugar and blocking ketosis), and 60+ percent of calories from healthy fats. The 75-gram protein ceiling surprises many women who’ve been told to maximize protein. Pelz is firm: for women in ketosis, the ceiling matters more than the floor.

    Hormone feasting (Manifestation and Nurture Phases): Up to 150 grams of complex carbohydrates from whole-food sources — sweet potatoes, lentils, black beans, squash, wild rice, tropical fruits, berries. These carbohydrates are not a dietary concession; they are the physiological substrate progesterone requires to synthesize. The woman who eats strict keto all month and wonders why her period is late and her pre-period anxiety is unbearable has been removing the very ingredient her body needs for hormonal stability.

    Notable Quotes

    On why universal fasting advice fails women:

    “While the scientific evidence is clear that fasting heals, there still exists one huge blind spot: A one-size-fits-all approach to fasting doesn’t work, especially for women.”

    This is the thesis in a sentence. The evidence for fasting is solid. The failure is in applying it without regard for the monthly hormonal context that governs how women’s bodies respond.

    On reframing fasting from deprivation to healing:

    “Fasting is not like any other diet. It is not a moment of deprivation; it’s a gift you give yourself that will allow your body and brain to recover from the stressors of the modern world.”

    This reframe matters for anyone whose relationship with food has involved a lot of restriction-and-punishment cycles. Pelz is positioning fasting as a self-care practice, not a control mechanism.

    On the cellular science:

    “Dr. Yoshinori Ohsumi’s landmark research revealed that in the absence of food our cells get stronger, not weaker. Instead of looking for nutrients outside the cell when food is scarce, that cell turns within and eats what’s inside.”

    The Nobel Prize framing is the book’s most effective credibility move. The image of cells cleaning themselves in the absence of food is visceral, and it genuinely represents the science.

    On what happens when women get the protocol right:

    “If there is anything that these women have taught me, it’s that once a woman knows how to build a fasting lifestyle around her cycle, she becomes unstoppable.”

    Pelz’s clinical enthusiasm is real, and earned from watching hundreds of thousands of people apply this framework.

    On the hormonal hierarchy:

    “The hormone oxytocin can calm cortisol. Cortisol spikes will cause increases in insulin, and surges in insulin have a direct effect over your sex hormones estrogen, progesterone, and testosterone.”

    This chain — and the implication that generating oxytocin through rest, pleasure, and connection is a hormonal intervention — is the book’s most counterintuitive and practically useful claim.

    On what diet culture actually did:

    “Most diets have blindly disconnected you from your body’s design, leading you straight into the arms of frustration, self-doubt, and distrust with your body.”

    For anyone who has spent years failing at advice that was never designed for their biology, this lands hard.

    On the necessity of carbohydrates before menstruation:

    “If estrogen thrives when insulin is low, progesterone thrives when cortisol is low. There is a precursor steroid hormone called DHEA that you need to make progesterone. If during this phase of your monthly cycle your cortisol spikes too much, you won’t have enough DHEA to make progesterone.”

    This passage explains, in plain biological terms, why the strictest dieters often have the worst PMS.

    Who Should Read This

    Read this if you:

    • Have tried intermittent fasting and experienced adverse effects — hair loss, worsening anxiety, disrupted cycles, no weight loss despite consistent effort
    • Are perimenopausal or postmenopausal and want a structured way to use fasting without worsening hormonal symptoms
    • Are experiencing PMS, irregular cycles, or hormonal weight gain that hasn’t responded to conventional diet advice
    • Have been living in chronic stress and want to understand how that stress is directly suppressing your hormones
    • Are already fasting and want to understand why you’ve plateaued

    You can skip this if you:

    • Have a history of disordered eating or restriction — the fasting framework here is developed enough that it warrants working through with a therapist or dietitian before self-applying
    • Are looking for clinical evidence at research-paper rigor; Pelz synthesizes well but extends beyond the published evidence base in places
    • Are a man, or are not interested in the hormonal-cycle framing (though the metabolic switching and autophagy science applies universally)

    A note of caution: Pelz is a chiropractor, not an endocrinologist, and some of her specific claims — particularly around toxic load and estrogen detox — are more speculative than the fasting science she builds her framework on. The core cycle-syncing logic is sound. The more specific mechanistic claims benefit from additional scrutiny. If you are managing thyroid conditions, type 2 diabetes, or adrenal fatigue, involve a physician before applying the condition-specific protocols in Appendix C.

    Related Books

    • The Obesity Code — Jason Fung: The foundational text on insulin and fasting; provides the scientific underpinning for Pelz’s metabolic framework and is more clinically rigorous on the insulin-weight connection.
    • In the Flo — Alisa Vitti: Cycle-syncing framework for food, exercise, and lifestyle; covers similar hormonal phase territory with more emphasis on living cyclically rather than therapeutic fasting specifically.
    • Glucose Revolution — Jessie Inchauspé: Blood sugar management and glucose spike reduction; complements Pelz’s insulin-estrogen model with practical tools for flattening glucose curves during the eating window.
    • Breaking Free from Emotional Eating — Geneen Roth: Important companion for anyone whose relationship with food involves restriction cycles; the hormonal explanation for food behaviors pairs well with Roth’s psychological framework.
    • The Hormone Cure — Sara Gottfried, M.D.: More clinically rigorous treatment of estrogen, progesterone, and cortisol imbalances; useful counterpoint for readers who want the endocrinology to go deeper than Pelz takes it.

  • Next Level by Stacy T. Sims: Summary, Key Ideas & Notable Quotes

    10 min read

    Why This Book Matters

    If you are a woman in your forties or fifties who has been exercising regularly, eating carefully, and watching your body change anyway — more belly fat, less muscle, less energy, less of everything you worked for — this book is for you. Not because it will tell you to try harder. But because it will tell you why everything you have been doing is working against your physiology, and exactly what to do instead.

    Next Level was written by Stacy T. Sims, PhD, an exercise physiologist and nutrition scientist who has spent her career studying how women’s physiology differs from men’s — and how dramatically wrong most mainstream fitness advice is for women at this stage of life. Sims spent years at Stanford University and later at the University of Waikato in New Zealand researching female athletic performance. Her previous book, ROAR (2016), focused on training and nutrition around the menstrual cycle. Next Level is its sequel: everything that happens when those cycles start to end.

    The book is co-written with Selene Yeager, an elite cyclist and endurance athlete who was living through perimenopause while they were writing it. That matters. This is not a theoretical text produced at clinical distance. It is written by two women who know what it feels like when the body you have trained for decades suddenly seems to be working against you — and who have the research to explain why, and what to do.

    Here is the core problem the book addresses: when estrogen and progesterone begin to decline, all the physiological functions those hormones were quietly performing — building muscle, regulating blood sugar, protecting bone, managing body temperature, keeping cortisol in check — start going undone. The symptoms women experience during menopause are not random misfortunes. They are the predictable downstream effects of specific hormonal signals going offline. And the standard response most women (and most doctors) reach for — eat less, do more cardio — makes nearly all of them worse.

    Sims’s prescription is specific, evidence-based, and often the opposite of conventional wisdom. That is what makes it worth reading.

    The Core Framework: Picking Up the Slack

    The animating concept behind Next Level is one the book introduces in the very first pages and returns to throughout: “What you’re really doing when you act on the advice in this book is picking up the slack and starting to do the work that your fluctuating and dwindling hormones have always done.”

    This reframe is important. For most of a woman’s life, estrogen and progesterone have been performing anabolic, metabolic, and regulatory work in the background — stimulating muscle protein synthesis, maintaining bone density, balancing cortisol, regulating blood sugar and fat storage. You did not need to think about these functions because your hormones were handling them. As they decline, those functions do not continue automatically. The work simply goes undone unless you intervene.

    Sims maps each lost hormonal function to a specific intervention:

    • Estrogen’s anabolic stimulus for muscle → Heavy lifting (low reps, high load)
    • Estrogen’s blood sugar regulation → Sprint interval training + strategic carbohydrate timing
    • Estrogen’s mitochondrial support → Both sprint intervals and plyometrics
    • Estrogen’s fast-twitch muscle and power signal → Plyometrics and heavy lifting combined
    • Estrogen’s bone remodeling signal → Plyometrics and resistance training
    • Progesterone’s cortisol regulation → Adequate sleep, post-workout nutrition, eliminating fasted training

    This is the map. Every specific recommendation in the book flows from it.

    Key Ideas

    Sprint Interval Training Is the Cardio You Actually Need

    The cardio most women default to during menopause — long, moderate-intensity sessions, the kind that feel virtuous and sustainable — is precisely the kind most likely to make things worse. Long steady-state cardio chronically elevates cortisol in women who already have elevated cortisol due to declining progesterone. The result is more abdominal fat storage, more muscle breakdown, and more fatigue, not less.

    What works instead is sprint interval training, or SIT. Genuinely short, genuinely all-out efforts — 10 to 40 seconds — with full recovery between them. The key word is “all-out.” Not hard. Not elevated heart rate. Maximal. A Tabata protocol (20 seconds all-out, 10 seconds rest, 6-8 rounds) done on a bike or with full-body movements like kettlebell swings. Hill repeats of 20-30 seconds going as hard as possible, then walking back. This level of intensity provides the metabolic stimulus that estrogen used to provide — improving insulin sensitivity, preserving lean mass, building mitochondrial density — while the brevity of the effort prevents the chronic cortisol elevation that moderate-intensity cardio creates.

    Two sessions per week is sufficient. The long run or easy bike ride does not disappear — it becomes active recovery on different days, not the primary training driver.

    Lift Heavy — Not Light, Not Moderate, Heavy

    The fitness industry has sold women on high-rep, low-weight training for decades, promising “toning” and “sculpting” without “bulking up.” For menopausal women, Sims is blunt: this advice is not just ineffective, it is actively unhelpful. High-rep light-weight training builds muscular endurance. Menopausal women need muscular strength.

    Estrogen was the primary driver of muscle stem cell activation — the biological process that repairs and builds muscle tissue. When estrogen declines, that signal drops precipitously. Research shows that removing estrogen from animal models causes muscle stem cell regeneration to fall 30 to 60 percent. The only training that can replace this stimulus is lifting heavy enough to recruit high-threshold motor units: compound movements (squats, deadlifts, rows, chest press) performed in the 3-6 rep range at near-maximal load.

    The downstream benefits extend far beyond appearance. Heavy lifting increases resting metabolic rate, improves joint stability and posture, reduces cardiovascular disease risk, strengthens bone, and produces the lean body mass that is the most significant determinant of fat metabolism in postmenopausal women. A study found that postmenopausal women had 33 percent lower fat burning during cardio than premenopausal women — and the entire difference was explained by the 9.5 pounds of lean mass they had lost.

    The Cortisol Paradox: Why Eating Less Makes You Store More Fat

    This is the concept that most often stops women cold when they first encounter it. They are eating less. They are exercising more. They are gaining belly fat. They are not imagining it, and they are not failures. They are caught in a cortisol paradox.

    Menopausal women have elevated baseline cortisol because progesterone — the hormone that kept cortisol in check — has declined. Adding long cardio sessions (which spike cortisol), training fasted (another cortisol spike), restricting calories (which triggers metabolic survival mode), and sleeping poorly (cortisol falls 6 times more slowly in sleep-deprived people) creates a self-reinforcing stress cascade. The body interprets this cascade as survival emergency and responds accordingly: break down muscle for fuel, store abdominal fat as an energy reserve, suppress the thyroid to conserve resources.

    The intervention that breaks the cycle is counterintuitive: eat enough (especially around training), replace long cardio with short intense intervals, add heavy lifting, and protect sleep. Not the “work harder, eat less” message women have been given. The opposite of it.

    The 30-Minute Recovery Window and the Leucine Threshold

    For muscle protein synthesis to occur, the body needs to receive a specific amino acid signal — approximately 3 to 3.5 grams of leucine per feeding — at the cellular level. This “leucine threshold” triggers the anabolic response. Meeting total daily protein without hitting the threshold at each meal does not produce the same effect.

    For menopausal women, the post-workout recovery window is 30 minutes — not the 2 to 3 hours that research in male subjects suggested. After hard training (sprint intervals, heavy lifting, endurance work), cortisol is high and the body is actively breaking down muscle. Eating 30-40 grams of high-quality protein (with sufficient leucine) within that 30-minute window stops the breakdown, lowers cortisol, and initiates muscle repair. Skipping post-workout eating in an attempt to “burn more fat” does the opposite: it extends the catabolic state, elevates blood sugar through cortisol-driven glycogen release, and drives fat storage.

    The practical math: 25 grams of whey protein provides about 2.5 grams of leucine. Meeting the 3-3.5 gram threshold requires 30+ grams of whey or equivalent animal protein. Plant-based athletes need roughly 50 grams of soy protein to match the leucine in 25 grams of whey — a commonly misunderstood gap.

    Plyometrics for Bone Density (10 Minutes, 3x a Week)

    Women can lose up to 20 percent of bone density in the five to seven years following menopause. Resistance training helps, but running and cycling — the cardio most women use — provide limited osteogenic stimulus because they involve repetitive single-plane loading rather than the multidirectional, varied-impact loading that triggers bone remodeling most effectively.

    Plyometrics — jump training — fill this gap. Even 10-20 jumps twice daily has been shown in research to produce measurable improvements in hip bone density after 16 weeks. Sims recommends 10 minutes of plyometric circuits three times per week, starting with beginner movements (squat jumps, jumping jacks, side hops) and building toward more advanced options (tuck jumps, speed skaters, burpees). The investment is small. The bone density, fast-twitch muscle preservation, and insulin sensitivity benefits are significant, and there is no training category more commonly neglected by women in this age group.

    Notable Quotes

    “What you’re really doing when you act on the advice in this book is picking up the slack and starting to do the work that your fluctuating and dwindling hormones have always done.”

    This is the book’s thesis in one sentence. Every exercise and nutrition prescription that follows is an answer to the question: which hormonal job just went undone, and how do I do it myself?

    “There’s a tendency for women to lift lighter weights for high repetitions, like picking up five-pound dumbbells and lifting them 20 times. This is often called ‘body sculpting’ by trainers, who promise women that they can ‘tone up’ without ‘getting bulky muscles.’ This mindset needs to go because it’s misleading, misguided, and honestly not helpful for women whose sex hormones, lean muscle mass, and strength are on a precipitous decline.”

    Sims is not gentle with the fitness industry’s treatment of menopausal women. Light weights are not a conservative starting point. They are the wrong tool for the job.

    “One of the first things that happens when the body isn’t getting the energy it needs is that it starts increasing body fat. Without enough energy to perform basic functions (let alone your long runs or strength workouts), your endocrine system signals for your body to start breaking down muscle and to store more fat, so you have a reserve of energy.”

    The explanation most women who are dieting and exercising and getting worse results have never heard. Not willpower failure. Survival biology.

    “For menopausal women, high-intensity sprint interval training sessions can provide the metabolic stimulus to trigger the performance-boosting body composition changes that our hormones helped us achieve in our premenopausal years. The key here is the intensity.”

    Intensity — not duration, not consistency, not moderate effort — is the operative word. The intensity of genuine all-out effort cannot be replicated by working “hard-ish” for longer.

    “Menopausal women often reach for soy because they want the plant estrogens to relieve menopausal symptoms like hot flashes. The problem is that you need twice as much soy to provide the muscle recovery benefits of animal-based protein like whey.”

    A specific, commonly misunderstood finding. Soy’s phytoestrogen content does not translate into equivalent muscle protein synthesis capacity.

    “Women in their forties are still in their athletic prime. We see that in inspirational athletes like seven-time world champion Rebecca Rusch, who didn’t even start bike racing until her late twenties and is still crushing competitions in her early fifties.”

    The cultural reframe the whole book rests on. Menopause is not the beginning of athletic decline. It is a transition that demands a specific response — and the response produces a body that can perform at the highest levels for decades.

    Who Should Read This

    Next Level is best suited for women in their forties or fifties — peri- or postmenopausal — who are already active and finding that what worked before is no longer working. If you have been training consistently, eating carefully, and watching your body composition change in the wrong direction anyway, this book explains why and tells you exactly what to change.

    It is also essential reading for women entering perimenopause who want to get ahead of the transition — the interventions are most effective when started early, before significant muscle and bone loss has accumulated.

    Coaches, trainers, and healthcare practitioners working with women in midlife will find it valuable for the specificity of its prescriptions. The book is more useful than most clinical resources for translating physiology into actionable programming.

    It is less suited for sedentary women who are just beginning to exercise. The protocols assume a baseline level of fitness and familiarity with training concepts. A complete beginner would benefit from starting with a simpler movement foundation before implementing the sprint and lifting protocols.

    Women primarily dealing with the non-fitness dimensions of menopause — hormonal symptoms, vaginal changes, cognitive shifts, MHT decisions — will find this book addresses those topics but is not the primary resource for them. The New Menopause by Mary Claire Haver is a better clinical companion for that dimension.

    ROAR — Stacy T. Sims: The predecessor to Next Level, covering training and nutrition optimization across the menstrual cycle for premenopausal women. Establishes the energy availability and nutrition timing principles that Next Level builds upon.

    The New Menopause — Mary Claire Haver: The clinical complement to Next Level. Where Sims focuses on exercise and nutrition, Haver covers hormonal symptom management, HRT options, and medical decision-making. Best read together.

    Good Energy — Casey Means: Covers metabolic health and blood sugar regulation from a precision medicine angle. Strong overlap with Next Level‘s nutrition content; more detailed on biomarker tracking.

    Outlive — Peter Attia: Covers the exercise science of longevity with significant overlap on strength training and cardiovascular training for long-term health. Approaches similar conclusions from different research; less women-specific but broader in scope.

  • The Power of Hormones by Max Nieuwdorp: Summary, Key Ideas & Review

    Book in one sentence: A practicing endocrinologist walks you through every major hormone in the human body, from insulin to oxytocin, and shows why they cannot be understood in isolation from each other.

    What Is The Power of Hormones About?

    Picture the standard medical model of your hormones: a tidy diagram of glands, each one producing its own molecule, each one working in its lane. The thyroid does thyroid things. The pancreas does pancreas things. The adrenals do adrenal things. Clean, separate, manageable.

    Max Nieuwdorp, a professor of internal medicine at Amsterdam University Medical Center, has spent twenty years watching that model fail his patients. His book is a correction. The endocrine system is not a list of glands. It is a communication network, and nothing in it operates alone. Estrogen affects cortisol. Cortisol suppresses the hormones that govern ovulation. Gut bacteria determine how sensitive your cells are to insulin. Stress disrupts thyroid conversion. That chain of influence is not theoretical. It is the reason a hard year can derail your menstrual cycle, a course of antibiotics can trigger months of metabolic disruption, and a sleep deficit can make weight loss feel physiologically impossible.

    The book covers everything: insulin, cortisol, thyroid, growth hormone, testosterone, estrogen, oxytocin, leptin, ghrelin, GLP-1. It moves through the human lifespan from conception to old age, organized as narrative history as much as science (the discovery of insulin, the cortisol story, how the contraceptive pill changed society). Nieuwdorp is not a wellness influencer extrapolating from mouse studies. He is a working clinician who has also published research on fecal microbiota transplantation and insulin sensitivity, and the distinction shows on every page.

    Why Insulin and Cortisol Matter More Than You Think for Weight

    For readers on a weight or eating journey, two chapters stand out: the ones on obesity and hunger, and the one on stress.

    Insulin: blessing and curse

    Nieuwdorp describes insulin as “both a blessing and a curse.” That is not a throwaway line. Insulin is essential to life (without it, glucose cannot enter cells and you die). But in chronic dysregulation, the same molecule becomes a driver of fat storage, systemic inflammation, and metabolic disease. Insulin resistance is the pivot: when cells stop responding to insulin’s signal, the pancreas compensates by producing more, and chronically elevated insulin promotes fat storage while blocking fat breakdown. The body cannot easily access its own stored energy.

    What makes the insulin chapter useful for this audience is that Nieuwdorp connects it to eating behavior, not just blood sugar numbers. The gut’s own satiety hormones (GLP-1, CCK) are released in response to food and normally help the body regulate intake. When insulin signaling is chronically disrupted, that whole feedback loop becomes less reliable. Hunger signals stop reflecting actual caloric need. The relationship between what you eat and how satisfied you feel gets decoupled.

    Cortisol and the cascade it triggers

    The stress chapter does something most popular health books skip: it shows the precise mechanism by which chronic stress becomes a weight and eating problem, not just a mood problem.

    Chronically elevated cortisol suppresses GnRH, which lowers FSH and LH, which shuts down ovarian production of estrogen and progesterone. It also impairs the conversion of inactive T4 to active T3 in peripheral tissues, compounding any subclinical thyroid dysfunction. It promotes leptin resistance, making the brain less able to detect that you have enough stored energy. It disrupts sleep architecture, reducing the deep sleep during which growth hormone is released and tissues repair.

    Nieuwdorp’s clinical example is not exotic: a high-achieving woman with twelve-hour workdays, five gym sessions per week, four to five hours of sleep, absent menstruation, and labs that read as normal. The treatment is not a hormone prescription. It is more food, less exercise intensity, and more sleep. The hormones are not malfunctioning; they are responding correctly to the load the system is under. Stress reduction, adequate calories, and sleep restoration are hormone therapies, whether or not anyone frames them that way.

    How Does Your Body Defend Its Weight Against You?

    The obesity chapter is where Nieuwdorp’s book earns its place on the shelf for anyone who has ever felt like their body was working against them during weight loss. Because it is, and he explains exactly how.

    Ghrelin is the primary hunger hormone, produced by the empty stomach. It drives hunger, stimulates dopamine release (creating food-seeking behavior), and enforces the hypothalamic weight set-point. In people with obesity, ghrelin stays elevated even when there is plenty of stored body fat, while the hypothalamus has become resistant to leptin (the satiety signal from fat tissue). The result: persistent hunger that does not reflect actual caloric need.

    When caloric restriction is sustained, the body mounts a three-part defense:

    1. Ghrelin rises (driving more hunger)
    2. Resting metabolic rate drops (burning fewer calories at rest)
    3. Spontaneous physical activity decreases (conserving energy without conscious awareness)

    That is not a failure of willpower. It is an adaptive physiological response executing a defense strategy. The set-point the hypothalamus is defending is not a number you chose. And it is not one you can override through discipline alone.

    “Ghrelin concentrations paradoxically decrease after gastric bypass surgery, despite the stomach being empty more of the time.”

    That one sentence reframes bariatric surgery entirely. Bariatric surgery works (and produces durable results) not primarily by restricting food intake, but by resetting the hormonal thermostat. GLP-1 receptor agonist medications work the same way: they mimic the gut’s own satiety hormones and shift what the hypothalamus is defending. Neither is “cheating.” Both are working at the level where the problem actually lives.

    What Makes This Book Different from Other Hormone Books

    A lot of hormone books on the market are written by functional medicine practitioners, coaches, or journalists. They tend to focus on a subset of hormones (usually estrogen, progesterone, and thyroid) and emphasize protocols: what to eat, what to supplement, what to test.

    Nieuwdorp is none of those things. He is a practicing endocrinologist with a research background, and this is a medically rigorous hormone book written for a general audience in a way that very few are. A few things set it apart:

    Historical narrative. Each hormone chapter is partly a history of how that hormone was discovered (the story of insulin’s discovery in 1921, the cortisol experiments, the early testosterone research). It grounds each concept in the actual scientific process and makes the mechanisms memorable.

    The full spectrum of hormones. Most hormone books skip oxytocin, growth hormone, ADH, parathyroid hormone, and the gut peptides. Nieuwdorp covers them all, which matters because the interactions are the whole point. You cannot understand why stress disrupts your period without understanding the hypothalamic-pituitary-adrenal axis and its relationship to GnRH. You cannot understand why your gut matters for metabolic health without understanding GLP-1 and its relationship to insulin sensitivity.

    Calibrated caution about self-treatment. Nieuwdorp writes: “It’s clear that you can’t replace or even simulate the body’s own functions by administering hormones. Playing around with hormone preparations yourself can also be dangerous, especially without medical supervision.” For a book that could easily have pitched the opposite message, this is worth noting. The endocrine system’s complexity is precisely why hormone intervention requires clinical oversight.

    What it does not offer is a protocol. Nieuwdorp is more interested in mechanism than prescription. Readers who want the “what to do” alongside the science will need companion books. The related books table below has suggestions.

    Is The Power of Hormones Worth Reading?

    Read this if you have been told your labs are normal while feeling anything but, you want the actual mechanistic explanation for why weight loss gets physiologically harder over time, you are using a GLP-1 medication and want to understand why it works, or you are someone who thinks in systems and wants the full picture before making any decision about your hormonal health.

    Skip it if you want a step-by-step protocol, a supplement list, or a dietary framework. Nieuwdorp is a scientist, not a health coach, and the book reflects that completely.

    One caveat: The density is real. Some chapters (the history sections especially) move slowly, and readers who want a quicker route to the weight-relevant material can focus on chapters 5 (obesity and hunger) and 6 (gut and metabolism) without losing much. The payoff for reading straight through is the cumulative sense of how deeply interconnected every hormone system is, and it requires patience to get there.

    Books Like The Power of Hormones

    BookAuthorBest For
    It’s Your HormonesGeoffrey RedmondReaders who want clinical depth on female sex hormones specifically
    The Hormone MythRobyn Stein DeLucaReaders skeptical of hormone-blame narratives; a useful counterweight
    Thinking, Fast and SlowDaniel KahnemanFor readers who like dense, evidence-heavy science books on how systems shape behavior
    The XX BrainLisa MosconiBrain imaging data on what estrogen loss does to cognition; extends Nieuwdorp’s perimenopause chapters
    Hormone IntelligenceAviva RommThe protocol-forward complement: where Nieuwdorp explains the mechanism, Romm prescribes the intervention